Neuroendocrine response to cold in Raynaud's syndrome.

Journal Article (Journal Article)

Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly higher levels of cortisol during a cold challenge than either ANA positive patients or normal controls, and exhibited significantly lower levels of plasma norepinephrine compared with normal controls. ANA positive patients did not differ significantly from normals in their neuroendocrine response to cold. It is suggested that the high plasma cortisol found in Raynaud's syndrome in the absence of ANA may be responsible for the vasospasticity in this group of patients.

Full Text

Duke Authors

Cited Authors

  • Surwit, RS; Allen, LM; Gilgor, RS; Schanberg, S; Kuhn, C; Duvic, M

Published Date

  • February 28, 1983

Published In

Volume / Issue

  • 32 / 9

Start / End Page

  • 995 - 1000

PubMed ID

  • 6600810

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(83)90930-x


  • eng

Conference Location

  • Netherlands