Failure of genetically selected miniature swine to model NIDDM.


Journal Article

Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic diet; and 4 mo of excess diabetogenic diet for obesification. Results of oral glucose tolerance and intravenous insulin tolerance tests conducted at the end of each regimen were compared. Hyperglycemia was not observed in any animals after any manipulation. Insulin sensitivity was also not influenced by diet. We conclude that F7 low-K miniature swine from this colony fail to model human non-insulin-dependent diabetes.

Full Text

Duke Authors

Cited Authors

  • Hand, MS; Surwit, RS; Rodin, J; Van Order, P; Feinglos, MN

Published Date

  • March 1, 1987

Published In

Volume / Issue

  • 36 / 3

Start / End Page

  • 284 - 287

PubMed ID

  • 3542650

Pubmed Central ID

  • 3542650

International Standard Serial Number (ISSN)

  • 0012-1797

Digital Object Identifier (DOI)

  • 10.2337/diab.36.3.284


  • eng

Conference Location

  • United States