Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice.

Journal Article (Journal Article)

The genetically obese mouse (C57BL/6J ob/ob) is a commonly used animal model of non-insulin-dependent diabetes mellitus. These mice show exaggerated glycemic responses during behavioral stress and adrenergic stimulation, but the precise glucoregulatory mechanisms are not well characterized. The ob/ob mice have multiple endocrine abnormalities, including elevated pituitary and circulating beta-endorphin levels; and a relationship between hyperglycemia and altered opioid function has been suspected. We now report that opiate antagonism with naltrexone potentiates hyperglycemic responses during stress and epinephrine challenge in obese mice. This effect of opioid blockade suggests that endogenous opioids inhibit stress- and epinephrine-induced hyperglycemia in the genetically obese mouse.

Full Text

Duke Authors

Cited Authors

  • McCubbin, JA; Surwit, RS; Kuhn, CM; Cochrane, C; Feinglos, MN

Published Date

  • July 1, 1989

Published In

Volume / Issue

  • 51 / 4

Start / End Page

  • 441 - 448

PubMed ID

  • 2549557

International Standard Serial Number (ISSN)

  • 0033-3174

Digital Object Identifier (DOI)

  • 10.1097/00006842-198907000-00007


  • eng

Conference Location

  • United States