Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.

Journal Article (Journal Article)

The obese (C57BL/6J ob/ob) mouse is a commonly used animal model of non-insulin-dependent diabetes mellitus. Recent experiments have shown that stress hyperglycemia can be classically conditioned in the obese but not in the lean mouse. In the present study, classical conditioning of insulin secretion was attempted in C57BL/6J obese and lean animals. For 21 days, obese and lean mice were exposed to a conditioned olfactory stimulus prior to and during eating. On the 22nd day, blood was sampled for all animals following presentation of the conditioned stimulus; testing was repeated 2 weeks later following an additional 4 days of conditioning. Results indicated an effect of conditioning, with significantly greater plasma insulin for trained than for untrained obese mice. That insulin secretion can be more easily conditioned in the obese mouse suggests that a cholinergic mechanism may be involved in the hyperinsulinemia characteristic of this animal.

Full Text

Duke Authors

Cited Authors

  • Morrell, EM; Surwit, RS; Kuhn, CM; Feinglos, MN; Cochrane, C

Published Date

  • 1988

Published In

Volume / Issue

  • 50 / 6

Start / End Page

  • 586 - 590

PubMed ID

  • 3070619

International Standard Serial Number (ISSN)

  • 0033-3174

Digital Object Identifier (DOI)

  • 10.1097/00006842-198811000-00004


  • eng

Conference Location

  • United States