Altered pituitary hormone response to naloxone in hypertension development.

Journal Article (Journal Article)

Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and beta-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and beta-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.

Full Text

Duke Authors

Cited Authors

  • McCubbin, JA; Surwit, RS; Williams, RB; Nemeroff, CB; McNeilly, M

Published Date

  • December 1989

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 636 - 644

PubMed ID

  • 2555303

International Standard Serial Number (ISSN)

  • 0194-911X

Digital Object Identifier (DOI)

  • 10.1161/01.hyp.14.6.636


  • eng

Conference Location

  • United States