Altered pituitary hormone response to naloxone in hypertension development.
Publication
, Journal Article
McCubbin, JA; Surwit, RS; Williams, RB; Nemeroff, CB; McNeilly, M
Published in: Hypertension
December 1989
Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and beta-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and beta-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inhibition of anterior pituitary function is altered in hypertension development.
Duke Scholars
Published In
Hypertension
DOI
ISSN
0194-911X
Publication Date
December 1989
Volume
14
Issue
6
Start / End Page
636 / 644
Location
United States
Related Subject Headings
- beta-Endorphin
- Stress, Psychological
- Naloxone
- Male
- Hypertension
- Hydrocortisone
- Humans
- Epinephrine
- Cardiovascular System & Hematology
- Blood Pressure
Citation
APA
Chicago
ICMJE
MLA
NLM
McCubbin, J. A., Surwit, R. S., Williams, R. B., Nemeroff, C. B., & McNeilly, M. (1989). Altered pituitary hormone response to naloxone in hypertension development. Hypertension, 14(6), 636–644. https://doi.org/10.1161/01.hyp.14.6.636
McCubbin, J. A., R. S. Surwit, R. B. Williams, C. B. Nemeroff, and M. McNeilly. “Altered pituitary hormone response to naloxone in hypertension development.” Hypertension 14, no. 6 (December 1989): 636–44. https://doi.org/10.1161/01.hyp.14.6.636.
McCubbin JA, Surwit RS, Williams RB, Nemeroff CB, McNeilly M. Altered pituitary hormone response to naloxone in hypertension development. Hypertension. 1989 Dec;14(6):636–44.
McCubbin, J. A., et al. “Altered pituitary hormone response to naloxone in hypertension development.” Hypertension, vol. 14, no. 6, Dec. 1989, pp. 636–44. Pubmed, doi:10.1161/01.hyp.14.6.636.
McCubbin JA, Surwit RS, Williams RB, Nemeroff CB, McNeilly M. Altered pituitary hormone response to naloxone in hypertension development. Hypertension. 1989 Dec;14(6):636–644.
Published In
Hypertension
DOI
ISSN
0194-911X
Publication Date
December 1989
Volume
14
Issue
6
Start / End Page
636 / 644
Location
United States
Related Subject Headings
- beta-Endorphin
- Stress, Psychological
- Naloxone
- Male
- Hypertension
- Hydrocortisone
- Humans
- Epinephrine
- Cardiovascular System & Hematology
- Blood Pressure