Life without myoglobin.

Journal Article (Review)

Hemoproteins are widely distributed among prokaryotes, unicellular eukaryotes, plants and animals [1]. Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria [1-3]. This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists [1-3]. Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin [4]. This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle.

Full Text

Duke Authors

Cited Authors

  • Garry, DJ; Meeson, A; Yan, Z; Williams, RS

Published Date

  • June 2000

Published In

Volume / Issue

  • 57 / 6

Start / End Page

  • 896 - 898

PubMed ID

  • 10950305

International Standard Serial Number (ISSN)

  • 1420-682X

Digital Object Identifier (DOI)

  • 10.1007/PL00000732

Language

  • eng

Conference Location

  • Switzerland