Age-dependent changes in expression of alpha 1-adrenergic receptors in rat myocardium.


Journal Article

The expression of alpha 1-adrenergic receptors within ventricular myocardium of rats ranging in age from 21 days of fetal life to 24 months after birth was measured from [125I] 2-(beta hydroxy phenyl) ethylaminomethyl tetralone binding isotherms. No difference was observed in binding affinity between any of the age groups studied. The number of alpha 1-adrenergic receptors was found to be 60-120% higher in membranes from fetal or immature rats up to 25 days of age when compared with adult animals. The increased expression of alpha 1-adrenergic receptors in the developing heart relative to that observed in adult heart is consistent with the hypothesis that alpha 1-adrenergic receptor stimulation may modulate protein synthesis and growth in mammalian myocardium.

Full Text

Duke Authors

Cited Authors

  • Schaffer, W; Williams, RS

Published Date

  • July 16, 1986

Published In

Volume / Issue

  • 138 / 1

Start / End Page

  • 387 - 391

PubMed ID

  • 3017323

Pubmed Central ID

  • 3017323

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/0006-291x(86)90293-7


  • eng

Conference Location

  • United States