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Role of receptor mechanisms in the adaptive response to habitual exercise.

Publication ,  Journal Article
Williams, RS
Published in: Am J Cardiol
April 26, 1985

Many of the physiologic adaptations that occur in response to habitual exercise are associated with changes in neuroendocrine control of specific cell and tissue functions. Because all of the hormones and neurotransmitters important to exercise physiology exert their effects at the cellular level by binding to specific receptors, alterations in receptor properties induced by physical conditioning constitute a potential biochemical mechanism underlying changes in neuroendocrine control that contribute to the altered physiology of the exercise-trained state. This article summarizes existing data concerning the effects of exercise conditioning on receptor properties in several tissues. Considerable evidence suggests that hypersensitivity of adipocyte beta 1-adrenergic receptors to catecholamine stimulation is a response to exercise training, and may contribute to the increased consumption of fat, as opposed to carbohydrate, as fuel for muscular work during submaximal exertion in trained subjects. Conversely, cardiac beta-adrenergic receptors appear to be unaltered by physical conditioning, such that the relative bradycardia of the trained state is not attributable to changes in receptor properties. Training-induced changes in skeletal muscle, vascular and bronchial smooth muscle, platelet and leukocyte adrenergic receptors have also been reported, but the published findings are either inconsistent or of uncertain physiologic significance at the current time.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

April 26, 1985

Volume

55

Issue

10

Start / End Page

68D / 73D

Location

United States

Related Subject Headings

  • Sympathetic Nervous System
  • Receptors, Adrenergic
  • Physical Exertion
  • Myocardium
  • Lipid Metabolism
  • Leukocytes
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Physiological Phenomena
  • Carbohydrate Metabolism
 

Citation

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Williams, R. S. (1985). Role of receptor mechanisms in the adaptive response to habitual exercise. Am J Cardiol, 55(10), 68D-73D. https://doi.org/10.1016/0002-9149(85)91057-4
Williams, R. S. “Role of receptor mechanisms in the adaptive response to habitual exercise.Am J Cardiol 55, no. 10 (April 26, 1985): 68D-73D. https://doi.org/10.1016/0002-9149(85)91057-4.
Williams RS. Role of receptor mechanisms in the adaptive response to habitual exercise. Am J Cardiol. 1985 Apr 26;55(10):68D-73D.
Williams, R. S. “Role of receptor mechanisms in the adaptive response to habitual exercise.Am J Cardiol, vol. 55, no. 10, Apr. 1985, pp. 68D-73D. Pubmed, doi:10.1016/0002-9149(85)91057-4.
Williams RS. Role of receptor mechanisms in the adaptive response to habitual exercise. Am J Cardiol. 1985 Apr 26;55(10):68D-73D.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

April 26, 1985

Volume

55

Issue

10

Start / End Page

68D / 73D

Location

United States

Related Subject Headings

  • Sympathetic Nervous System
  • Receptors, Adrenergic
  • Physical Exertion
  • Myocardium
  • Lipid Metabolism
  • Leukocytes
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Physiological Phenomena
  • Carbohydrate Metabolism