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Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism.

Publication ,  Journal Article
Williams, RS; Guthrow, CE; Lefkowitz, RJ
Published in: J Clin Endocrinol Metab
March 1979

Lymphocytes from 12 patients with untreated hyperthyroidism were compared to lymphocytes from age- and sex-matched euthyroid control subjects to test the hypothesis that alterations in beta-adrenergic response mechanisms occur in human hyperthyroidism. The binding of (-)[3H]dihydroalprenolol, a compound previously shown in these cells to label binding sites having the characteristics of beta-adrenergic receptors, was assayed and no significant difference was found between the two groups. In addition, the accumulation of cAMP in response to isoproterenol was determined by RIA and, again, no difference was found.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

March 1979

Volume

48

Issue

3

Start / End Page

503 / 505

Location

United States

Related Subject Headings

  • Thyroxine
  • Theophylline
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Male
  • Lymphocytes
  • Isoproterenol
  • Hyperthyroidism
  • Humans
  • Female
 

Citation

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ICMJE
MLA
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Williams, R. S., Guthrow, C. E., & Lefkowitz, R. J. (1979). Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. J Clin Endocrinol Metab, 48(3), 503–505. https://doi.org/10.1210/jcem-48-3-503
Williams, R. S., C. E. Guthrow, and R. J. Lefkowitz. “Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism.J Clin Endocrinol Metab 48, no. 3 (March 1979): 503–5. https://doi.org/10.1210/jcem-48-3-503.
Williams RS, Guthrow CE, Lefkowitz RJ. Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. J Clin Endocrinol Metab. 1979 Mar;48(3):503–5.
Williams, R. S., et al. “Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism.J Clin Endocrinol Metab, vol. 48, no. 3, Mar. 1979, pp. 503–05. Pubmed, doi:10.1210/jcem-48-3-503.
Williams RS, Guthrow CE, Lefkowitz RJ. Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. J Clin Endocrinol Metab. 1979 Mar;48(3):503–505.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

March 1979

Volume

48

Issue

3

Start / End Page

503 / 505

Location

United States

Related Subject Headings

  • Thyroxine
  • Theophylline
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic
  • Male
  • Lymphocytes
  • Isoproterenol
  • Hyperthyroidism
  • Humans
  • Female