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Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits.

Publication ,  Journal Article
Wilson, LB; Dyke, CK; Parsons, D; Wall, PT; Pawelczyk, JA; Williams, RS; Mitchell, JH
Published in: J Appl Physiol (1985)
November 1995

The purpose of this study was to determine whether the reflex hemodynamic responses to static contraction of predominately glycolytic muscle are greater than the changes elicited by primarily oxidative muscle. Low-frequency electrical stimulation (continuous 21 days) of the tibial nerve of one hindlimb of adult rabbits converted the metabolic characteristics of the predominately glycolytic gastrocnemius to a muscle that was primarily oxidative. After 21 days of stimulation, the rabbits were decerebrated, and static contraction of the glycolytic muscle (unstimulated gastrocnemius) initially decreased heart rate (HR; -16 +/- 3 beats/min) and mean arterial pressure (MAP; -17 +/- 3 mmHg). Thereafter, MAP increased 13 +/- 3 mmHg above baseline. Static contraction of the oxidative muscle (stimulated gastrocnemius) produced similar decreases in HR and MAP (-12 +/- 4 beats/min and -12 +/- 3 mmHg, respectively). However, the subsequent increase in MAP (8 +/- 3 mmHg; above baseline) was less than that evoked by contraction of the glycolytic muscle. The responses evoked by stretch of each muscle and high-intensity electrical stimulation were the same, indicating that the afferents from the muscle were not destroyed by the chronic-stimulation technique. These results support the hypothesis that metabolic by-products play a role in the pressor response to static contraction of skeletal muscle. In addition, these data confirm that contraction of predominately oxidative muscle can evoke a reflex pressor response, albeit smaller than the change elicited from primarily glycolytic muscle.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

November 1995

Volume

79

Issue

5

Start / End Page

1744 / 1752

Location

United States

Related Subject Headings

  • Rabbits
  • Physiology
  • Muscle, Skeletal
  • Isotonic Contraction
  • Hemodynamics
  • Evoked Potentials, Motor
  • Electric Stimulation
  • Animals
  • Analysis of Variance
  • 11 Medical and Health Sciences
 

Citation

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Wilson, L. B., Dyke, C. K., Parsons, D., Wall, P. T., Pawelczyk, J. A., Williams, R. S., & Mitchell, J. H. (1995). Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. J Appl Physiol (1985), 79(5), 1744–1752. https://doi.org/10.1152/jappl.1995.79.5.1744
Wilson, L. B., C. K. Dyke, D. Parsons, P. T. Wall, J. A. Pawelczyk, R. S. Williams, and J. H. Mitchell. “Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits.J Appl Physiol (1985) 79, no. 5 (November 1995): 1744–52. https://doi.org/10.1152/jappl.1995.79.5.1744.
Wilson LB, Dyke CK, Parsons D, Wall PT, Pawelczyk JA, Williams RS, et al. Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. J Appl Physiol (1985). 1995 Nov;79(5):1744–52.
Wilson, L. B., et al. “Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits.J Appl Physiol (1985), vol. 79, no. 5, Nov. 1995, pp. 1744–52. Pubmed, doi:10.1152/jappl.1995.79.5.1744.
Wilson LB, Dyke CK, Parsons D, Wall PT, Pawelczyk JA, Williams RS, Mitchell JH. Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. J Appl Physiol (1985). 1995 Nov;79(5):1744–1752.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

November 1995

Volume

79

Issue

5

Start / End Page

1744 / 1752

Location

United States

Related Subject Headings

  • Rabbits
  • Physiology
  • Muscle, Skeletal
  • Isotonic Contraction
  • Hemodynamics
  • Evoked Potentials, Motor
  • Electric Stimulation
  • Animals
  • Analysis of Variance
  • 11 Medical and Health Sciences