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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.

Publication ,  Journal Article
Rothermel, B; Vega, RB; Yang, J; Wu, H; Bassel-Duby, R; Williams, RS
Published in: J Biol Chem
March 24, 2000

Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enriched calcineurin interacting protein), that are expressed most abundantly in striated muscles and that form a physical complex with calcineurin A. MCIP1 is encoded by DSCR1, a gene located in the Down syndrome critical region. Expression of the MCIP family of proteins is up-regulated during muscle differentiation, and their forced overexpression inhibits calcineurin signaling to a muscle-specific target gene in a myocyte cell background. Binding of MCIP1 to calcineurin A requires sequence motifs that resemble calcineurin interacting domains found in NFAT proteins. The inhibitory action of MCIP1 involves a direct association with the catalytic domain of calcineurin, rather than interference with the function of downstream components of the calcineurin signaling pathway. The interaction between MCIP proteins and calcineurin may modulate calcineurin-dependent pathways that control hypertrophic growth and selective programs of gene expression in striated muscles.

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Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

March 24, 2000

Volume

275

Issue

12

Start / End Page

8719 / 8725

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Transcription Factors
  • Tetradecanoylphorbol Acetate
  • Signal Transduction
  • Proteins
  • Protein Binding
  • Myogenic Regulatory Factors
  • Muscle, Skeletal
  • Muscle Proteins
  • Multigene Family
 

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Rothermel, B., Vega, R. B., Yang, J., Wu, H., Bassel-Duby, R., & Williams, R. S. (2000). A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem, 275(12), 8719–8725. https://doi.org/10.1074/jbc.275.12.8719
Rothermel, B., R. B. Vega, J. Yang, H. Wu, R. Bassel-Duby, and R. S. Williams. “A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.J Biol Chem 275, no. 12 (March 24, 2000): 8719–25. https://doi.org/10.1074/jbc.275.12.8719.
Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem. 2000 Mar 24;275(12):8719–25.
Rothermel, B., et al. “A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.J Biol Chem, vol. 275, no. 12, Mar. 2000, pp. 8719–25. Pubmed, doi:10.1074/jbc.275.12.8719.
Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem. 2000 Mar 24;275(12):8719–8725.

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

March 24, 2000

Volume

275

Issue

12

Start / End Page

8719 / 8725

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Transcription Factors
  • Tetradecanoylphorbol Acetate
  • Signal Transduction
  • Proteins
  • Protein Binding
  • Myogenic Regulatory Factors
  • Muscle, Skeletal
  • Muscle Proteins
  • Multigene Family