Transgenic animals in integrative biology: approaches and interpretations of outcome.
Journal Article (Journal Article;Review)
Technological innovations in methods for genetic manipulation of laboratory animals and in techniques for assessment of cardiovascular, respiratory, behavioral, and metabolic physiology in mouse models afford unprecedented opportunities for research in integrative biology. We provide here an overview of basic and advanced techniques for generation of transgenic mice and a discussion of how transgenic technology can be most advantageously applied to important physiological questions that can be addressed only within the intact organism.
Full Text
Duke Authors
Cited Authors
- Williams, RS; Wagner, PD
Published Date
- March 2000
Published In
Volume / Issue
- 88 / 3
Start / End Page
- 1119 - 1126
PubMed ID
- 10710411
International Standard Serial Number (ISSN)
- 8750-7587
Digital Object Identifier (DOI)
- 10.1152/jappl.2000.88.3.1119
Language
- eng
Conference Location
- United States