Transgenic animals in integrative biology: approaches and interpretations of outcome.

Journal Article (Journal Article;Review)

Technological innovations in methods for genetic manipulation of laboratory animals and in techniques for assessment of cardiovascular, respiratory, behavioral, and metabolic physiology in mouse models afford unprecedented opportunities for research in integrative biology. We provide here an overview of basic and advanced techniques for generation of transgenic mice and a discussion of how transgenic technology can be most advantageously applied to important physiological questions that can be addressed only within the intact organism.

Full Text

Duke Authors

Cited Authors

  • Williams, RS; Wagner, PD

Published Date

  • March 2000

Published In

Volume / Issue

  • 88 / 3

Start / End Page

  • 1119 - 1126

PubMed ID

  • 10710411

International Standard Serial Number (ISSN)

  • 8750-7587

Digital Object Identifier (DOI)

  • 10.1152/jappl.2000.88.3.1119

Language

  • eng

Conference Location

  • United States