Skip to main content

Regulation of stroke volume during submaximal and maximal upright exercise in normal man.

Publication ,  Journal Article
Higginbotham, MB; Morris, KG; Williams, RS; McHale, PA; Coleman, RE; Cobb, FR
Published in: Circ Res
February 1986

To characterize the hemodynamic factors that regulate stroke volume during upright exercise in normal man, 24 asymptomatic male volunteers were evaluated by simultaneous right heart catheterization, radionuclide angiography, and expired gas analysis during staged upright bicycle exercise to exhaustion. From rest to peak exercise, oxygen consumption increased from 0.33 to 2.55 liters/min (7.7-fold), cardiac index increased from 3.0 to 9.7 liters/min per m2 (3.2-fold), and arteriovenous oxygen difference increased from 5.8 to 14.1 vol% (2.5-fold). The increase in cardiac index resulted from an increase in heart rate from 73 to 167 beats/min (2.5-fold), and an increase in left ventricular stroke volume index from 41 to 58 ml/m2 (1.4-fold). During low levels of exercise, there was a linear increase in cardiac index due to an increase in both heart rate and stroke volume index; stroke volume index increased as a result of an increase in left ventricular filling pressure and end-diastolic volume index and, to a much smaller extent, a decrease in end-systolic volume index. During high levels of exercise, further increases in cardiac index resulted entirely from an increase in heart rate, since stroke volume index increased no further. Left ventricular end-diastolic volume index decreased despite a linear increase in pulmonary artery wedge pressure; stroke volume index was maintained by a further decrease in end-systolic volume index. The degree to which stroke volume index increased during exercise in individuals correlated with the change in end-diastolic volume index (r = 0.66) but not with the change in end-systolic volume index (r = 0.07). Thus, the mechanism by which left ventricular stroke volume increases during upright exercise in man is dependent upon the changing relationship between heart rate, left ventricular filling, and left ventricular contractility. At low levels of exertion, an increase in left ventricular filling pressure and end-diastolic volume are important determinants of the stroke volume response through the Starling mechanism. At high levels of exertion, the exercise tachycardia is accompanied by a decrease in end-diastolic volume despite a progressive increase in filling pressure, so that stroke volume must be maintained by a decrease in end-systolic volume.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Circ Res

DOI

ISSN

0009-7330

Publication Date

February 1986

Volume

58

Issue

2

Start / End Page

281 / 291

Location

United States

Related Subject Headings

  • Stroke Volume
  • Pulmonary Wedge Pressure
  • Posture
  • Physical Exertion
  • Middle Aged
  • Male
  • Humans
  • Hemodynamics
  • Heart Ventricles
  • Heart Rate
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Higginbotham, M. B., Morris, K. G., Williams, R. S., McHale, P. A., Coleman, R. E., & Cobb, F. R. (1986). Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res, 58(2), 281–291. https://doi.org/10.1161/01.res.58.2.281
Higginbotham, M. B., K. G. Morris, R. S. Williams, P. A. McHale, R. E. Coleman, and F. R. Cobb. “Regulation of stroke volume during submaximal and maximal upright exercise in normal man.Circ Res 58, no. 2 (February 1986): 281–91. https://doi.org/10.1161/01.res.58.2.281.
Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR. Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res. 1986 Feb;58(2):281–91.
Higginbotham, M. B., et al. “Regulation of stroke volume during submaximal and maximal upright exercise in normal man.Circ Res, vol. 58, no. 2, Feb. 1986, pp. 281–91. Pubmed, doi:10.1161/01.res.58.2.281.
Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR. Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res. 1986 Feb;58(2):281–291.

Published In

Circ Res

DOI

ISSN

0009-7330

Publication Date

February 1986

Volume

58

Issue

2

Start / End Page

281 / 291

Location

United States

Related Subject Headings

  • Stroke Volume
  • Pulmonary Wedge Pressure
  • Posture
  • Physical Exertion
  • Middle Aged
  • Male
  • Humans
  • Hemodynamics
  • Heart Ventricles
  • Heart Rate