Autonomic mechanisms of training bradycardia: beta-adrenergic receptors in humans.

Published

Journal Article

To address the autonomic mechanisms underlying the bradycardia of physical training in human subjects, we performed a cross-sectional study comparing the heart-rate responses to graded doses of isoproterenol in 7 elite marathon runners and 7 age-matched controls, and a longitudinal study in 12 normal volunteers of the effects of 6 wk of intense physical training on lymphocyte beta-adrenergic receptors identified by l-[3H]dihydroalprenolol. We observed no significant differences between marathoners and controls in the dose of isoproterenol that produced a 25-beat/min increment in heart rate, either in the absence (1.9 +/- 0.6 vs. 2.5 +/- 0.6 microgram; P, 0.509) or in the presence of cholinergic blockade (4.4 +/- 1.3 vs. 3.1 +/- 0.4 microgram: P, 0.320). Likewise, we observed no effects of physical training on lymphocyte beta-adrenergic receptors in terms of receptors number (53 +/- 11 vs. 56 +/- 10 fmol/mg protein) or receptor affinity (Kd 4.0 +/- 0.7 vs. 3.6 +/- 0.7 nM) (P, 0.9178). Although our data cannot exclude reduced chronotropic sensitivity to catecholamines as contributing to lowered heart rate in some highly conditioned individuals, these results are consistent with the hypothesis that altered neuronal input to the sinus node is usually a more important mechanism of training bradycardia.

Full Text

Duke Authors

Cited Authors

  • Williams, RS; Eden, RS; Moll, ME; Lester, RM; Wallace, AG

Published Date

  • November 1, 1981

Published In

Volume / Issue

  • 51 / 5

Start / End Page

  • 1232 - 1237

PubMed ID

  • 6271713

Pubmed Central ID

  • 6271713

International Standard Serial Number (ISSN)

  • 0161-7567

Digital Object Identifier (DOI)

  • 10.1152/jappl.1981.51.5.1232

Language

  • eng

Conference Location

  • United States