Skip to main content

Pretranslational regulation of myoglobin gene expression.

Publication ,  Journal Article
Underwood, LE; Williams, RS
Published in: Am J Physiol
April 1987

We have used blot hybridization techniques and a specific anti-sense RNA probe to determine whether variation in myoglobin gene expression among mammalian striated muscles is attributable to pretranslational regulatory events. We observed that myoglobin mRNA was expressed to approximately 10- and 5-fold greater levels, respectively, in cardiac and soleus (slow-twitch, oxidative, skeletal) muscles of adult rabbits than in tibialis anterior (fast-twitch, glycolytic, skeletal) muscles. Furthermore, when oxidative capacity of tibialis anterior muscles was increased by 21 days of indirect electrical stimulation, a model of exercise conditioning, myoglobin mRNA content increased approximately 15-fold. We conclude that pretranslational mechanisms are important in regulation of myoglobin gene expression in mammalian muscles.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

April 1987

Volume

252

Issue

4 Pt 1

Start / End Page

C450 / C453

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Rabbits
  • RNA, Messenger
  • RNA Processing, Post-Transcriptional
  • Oxygen
  • Myoglobin
  • Myocardium
  • Muscles
  • Gene Expression Regulation
  • Electric Stimulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Underwood, L. E., & Williams, R. S. (1987). Pretranslational regulation of myoglobin gene expression. Am J Physiol, 252(4 Pt 1), C450–C453. https://doi.org/10.1152/ajpcell.1987.252.4.C450
Underwood, L. E., and R. S. Williams. “Pretranslational regulation of myoglobin gene expression.Am J Physiol 252, no. 4 Pt 1 (April 1987): C450–53. https://doi.org/10.1152/ajpcell.1987.252.4.C450.
Underwood LE, Williams RS. Pretranslational regulation of myoglobin gene expression. Am J Physiol. 1987 Apr;252(4 Pt 1):C450–3.
Underwood, L. E., and R. S. Williams. “Pretranslational regulation of myoglobin gene expression.Am J Physiol, vol. 252, no. 4 Pt 1, Apr. 1987, pp. C450–53. Pubmed, doi:10.1152/ajpcell.1987.252.4.C450.
Underwood LE, Williams RS. Pretranslational regulation of myoglobin gene expression. Am J Physiol. 1987 Apr;252(4 Pt 1):C450–C453.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

April 1987

Volume

252

Issue

4 Pt 1

Start / End Page

C450 / C453

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Rabbits
  • RNA, Messenger
  • RNA Processing, Post-Transcriptional
  • Oxygen
  • Myoglobin
  • Myocardium
  • Muscles
  • Gene Expression Regulation
  • Electric Stimulation