The role of modulatory calcineurin-interacting proteins in calcineurin signaling.

Journal Article (Journal Article;Review)

Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like proteins, are a recently described family of small, structurally related proteins that are preferentially expressed in heart, skeletal muscle, and brain. MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure. Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice attenuates the hypertrophic response to a broad range of stimuli. This review summarizes work from a number of laboratories on the structure, regulation, and function of MCIP proteins.

Full Text

Duke Authors

Cited Authors

  • Rothermel, BA; Vega, RB; Williams, RS

Published Date

  • January 2003

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 15 - 21

PubMed ID

  • 12554096

International Standard Serial Number (ISSN)

  • 1050-1738

Digital Object Identifier (DOI)

  • 10.1016/s1050-1738(02)00188-3


  • eng

Conference Location

  • United States