M6P/IGF2R imprinting evolution in mammals.


Journal Article

Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is not imprinted in monotremes and does not encode for a receptor that binds IGF2. In contrast, M6P/IGF2R is imprinted in a didelphid marsupial, the opossum, but it strikingly lacks the differentially methylated CpG island in intron 2 postulated to be involved in imprint control. Thus, invasive placentation and gestational fetal growth are not required for imprinted genes to evolve. Unless there was convergent evolution of M6P/ IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes.

Full Text

Cited Authors

  • Killian, JK; Byrd, JC; Jirtle, JV; Munday, BL; Stoskopf, MK; MacDonald, RG; Jirtle, RL

Published Date

  • April 2000

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 707 - 716

PubMed ID

  • 10882106

Pubmed Central ID

  • 10882106

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/s1097-2765(00)80249-x


  • eng

Conference Location

  • United States