Metalloprotein design.

Journal Article (Journal Article;Review)

The rational design of novel proteins offers a new method of studying structure and function, and makes possible the construction of new biomaterials. The richness of metal chemistry, the relative ease of creating stable complexes, and the remarkable degree of subtle, highly specific control of reactivity imposed by the protein matrix upon the metal center make metalloprotein design a very fruitful area for the exploration and application of design techniques. So far, most designs have concentrated on the exploration of simple metal-chelation properties. Even so, this has led to the development of new methods for protein stabilization and affinity purification, of metal biosensors, of novel strategies for control of protein activity, and of model systems for the exploration of fundamental principles of molecular recognition.

Full Text

Duke Authors

Cited Authors

  • Hellinga, HW

Published Date

  • August 1996

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 437 - 441

PubMed ID

  • 8768904

International Standard Serial Number (ISSN)

  • 0958-1669

Digital Object Identifier (DOI)

  • 10.1016/s0958-1669(96)80121-2


  • eng

Conference Location

  • England