The construction of metal centers in proteins by rational design.

Journal Article (Journal Article;Review)

Metalloprotein properties result from the interplay between coordination requirements of the metal center, protein stability, and modulation of the metal center by the surrounding protein matrix. Simple metal centers, which exercise control over the protein by affecting stability or enzyme activity, have been created by rational design. Complex centers, which require control by the protein matrix, have also been constructed.

Full Text

Duke Authors

Cited Authors

  • Hellinga, HW

Published Date

  • January 1, 1998

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • R1 - R8

PubMed ID

  • 9502313

International Standard Serial Number (ISSN)

  • 1359-0278

Digital Object Identifier (DOI)

  • 10.1016/S1359-0278(98)00001-7


  • eng

Conference Location

  • England