Postprandial cholecystokinin release and gastric emptying in patients with bulimia nervosa.

Journal Article (Journal Article)

This study was designed to investigate the biological underpinnings of the observed deficit in satiety in patients with bulimia nervosa. Eight women with bulimia nervosa and 10 age- and weight-matched control subjects consumed three laboratory meals consisting of 200, 400, and 600 g of a radiolabeled liquid meal. For 1 h after each meal, blood samples were obtained at 10-min intervals for measurement of cholecystokinin concentration and gastric emptying was measured. Subjects also completed perceptual rating scales at 10-min intervals. Compared with control subjects, patients with bulimia nervosa showed a blunting of postprandial cholecystokinin release, particularly with larger meal sizes, as well as delayed gastric emptying. Increasing meal size was associated with increased desire to binge eat in patients but not in control subjects. These data lend support to a model in which increased gastric capacity, perhaps resulting from repeated binge eating, gives rise to delayed gastric emptying and blunted postprandial cholecystokinin release, leading to an impaired satiety response, which tends to perpetuate the illness.

Full Text

Duke Authors

Cited Authors

  • Devlin, MJ; Walsh, BT; Guss, JL; Kissileff, HR; Liddle, RA; Petkova, E

Published Date

  • January 1997

Published In

Volume / Issue

  • 65 / 1

Start / End Page

  • 114 - 120

PubMed ID

  • 8988922

International Standard Serial Number (ISSN)

  • 0002-9165

Digital Object Identifier (DOI)

  • 10.1093/ajcn/65.1.114


  • eng

Conference Location

  • United States