Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract.

Journal Article (Journal Article)

The purpose of this study was to examine the distribution and localization of an intestinal cholecystokinin (CCK)-releasing factor, called luminal CCK-releasing factor (LCRF), in the gastrointestinal tract and pancreas of the rat. RIA analysis indicates that LCRF immunoreactivity is found throughout the gut including the pancreas, stomach, duodenum, jejunum, ileum, and colon with the highest levels in the small intestine. Immunohistochemistry analysis shows LCRF immunoreactivity staining in intestinal villi, Brunner's glands of the duodenum, the duodenal myenteric plexus, gastric pits, pancreatic ductules, and pancreatic islets. These results indicate potential sources for secretagogue-stimulated release of luminal LCRF and support the hypothesis that LCRF is secreted into the intestinal lumen to stimulate CCK release from mucosal CCK cells.

Full Text

Duke Authors

Cited Authors

  • Tarasova, N; Spannagel, AW; Green, GM; Gomez, G; Reed, JT; Thompson, JC; Hellmich, MR; Reeve, JR; Liddle, RA; Greeley, GH

Published Date

  • December 1997

Published In

Volume / Issue

  • 138 / 12

Start / End Page

  • 5550 - 5554

PubMed ID

  • 9389543

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/endo.138.12.5554


  • eng

Conference Location

  • United States