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Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats.

Publication ,  Journal Article
Spannagel, AW; Nakano, I; Tawil, T; Chey, WY; Liddle, RA; Green, GM
Published in: Am J Physiol
January 1996

Exposure to higher levels of fat in the diet increases the secretion of fat-digesting enzymes in pancreatic juice. This study examines the functional consequences of this phenomenon and demonstrates that adapting rats to high fat (triglyceride) loads increases the release of cholecystokinin (CCK) and the pancreatic secretory response to intraduodenal fat. Lipolytic activity in the small intestine was also higher in adapted rats. Exchanging pancreatic juice from unadapted rats with pancreatic juice from adapted rats decreased the response to fat in adapted rats and increased the response to fat in unadapted rats. Infusing oleic acid into unadapted rats stimulated CCK secretion and pancreatic exocrine secretion to levels observed with triglycerides in adapted rats. Pancreatic exocrine secretion in response to intraduodenal fat in rats adapted to a high-fat (20%) diet were significantly higher than the responses seen in rats fed a low-fat (5%) diet. Adaptation to fat increases the pancreatic secretory and plasma CCK responses to fat, apparently by increasing the efficiency of triglyceride digestion and thereby increasing CCK release.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1996

Volume

270

Issue

1 Pt 1

Start / End Page

G128 / G135

Location

United States

Related Subject Headings

  • Triglycerides
  • Time Factors
  • Secretin
  • Rats, Wistar
  • Rats
  • Pancreatic Juice
  • Pancreas
  • Oleic Acid
  • Male
  • Lipolysis
 

Citation

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Spannagel, A. W., Nakano, I., Tawil, T., Chey, W. Y., Liddle, R. A., & Green, G. M. (1996). Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats. Am J Physiol, 270(1 Pt 1), G128–G135. https://doi.org/10.1152/ajpgi.1996.270.1.G128
Spannagel, A. W., I. Nakano, T. Tawil, W. Y. Chey, R. A. Liddle, and G. M. Green. “Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats.Am J Physiol 270, no. 1 Pt 1 (January 1996): G128–35. https://doi.org/10.1152/ajpgi.1996.270.1.G128.
Spannagel AW, Nakano I, Tawil T, Chey WY, Liddle RA, Green GM. Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats. Am J Physiol. 1996 Jan;270(1 Pt 1):G128–35.
Spannagel, A. W., et al. “Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats.Am J Physiol, vol. 270, no. 1 Pt 1, Jan. 1996, pp. G128–35. Pubmed, doi:10.1152/ajpgi.1996.270.1.G128.
Spannagel AW, Nakano I, Tawil T, Chey WY, Liddle RA, Green GM. Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats. Am J Physiol. 1996 Jan;270(1 Pt 1):G128–G135.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1996

Volume

270

Issue

1 Pt 1

Start / End Page

G128 / G135

Location

United States

Related Subject Headings

  • Triglycerides
  • Time Factors
  • Secretin
  • Rats, Wistar
  • Rats
  • Pancreatic Juice
  • Pancreas
  • Oleic Acid
  • Male
  • Lipolysis