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Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors.

Publication ,  Journal Article
Figlewicz, DP; Nadzan, AM; Sipols, AJ; Green, PK; Liddle, RA; Porte, D; Woods, SC
Published in: Am J Physiol
October 1992

Intraventricular cholecystokinin COOH-terminal octapeptide (CCK-8) decreases meal size in the meal-trained baboon. In the present study, we tested whether this action is mediated by CCK-A receptors, CCK-B receptors, or both. Intraventricular administration of the selective CCK-A receptor agonist A71623 at 1 and 10 nmol/kg suppressed 30-min meal size 69 +/- 22% and 75 +/- 7%, respectively. Additionally, intraventricular A71623 was equipotent to CCK-8 at 1 nmol/kg (% suppression of meal by CCK = 59 +/- 17). However, intraventricular administration of the CCK-B receptor agonist A63387 at 10 nmol/kg had no effect on 30-min meal size (% suppression = 18 +/- 29). Intravenous administration of 10 nmol/kg A71623 did not result in an alteration of meal size, but prandial plasma insulin and glucose responses were delayed and blunted. Basal plasma insulin levels doubled after intravenous administration of A71623. Both behavioral and metabolic responses to A71623 in the baboon are virtually identical to those we have previously observed after CCK-8 treatment. Thus we conclude that the predominant receptor population with which intraventricular CCK-8 interacts are type-A CCK receptors that are accessible to the ventricular system of the baboon.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

October 1992

Volume

263

Issue

4 Pt 2

Start / End Page

R863 / R867

Location

United States

Related Subject Headings

  • Tetragastrin
  • Sincalide
  • Receptors, Cholecystokinin
  • Papio
  • Oligopeptides
  • Male
  • Insulin
  • Injections, Intraventricular
  • Fasting
  • Eating
 

Citation

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MLA
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Figlewicz, D. P., Nadzan, A. M., Sipols, A. J., Green, P. K., Liddle, R. A., Porte, D., & Woods, S. C. (1992). Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors. Am J Physiol, 263(4 Pt 2), R863–R867. https://doi.org/10.1152/ajpregu.1992.263.4.R863
Figlewicz, D. P., A. M. Nadzan, A. J. Sipols, P. K. Green, R. A. Liddle, D. Porte, and S. C. Woods. “Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors.Am J Physiol 263, no. 4 Pt 2 (October 1992): R863–67. https://doi.org/10.1152/ajpregu.1992.263.4.R863.
Figlewicz DP, Nadzan AM, Sipols AJ, Green PK, Liddle RA, Porte D, et al. Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors. Am J Physiol. 1992 Oct;263(4 Pt 2):R863–7.
Figlewicz, D. P., et al. “Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors.Am J Physiol, vol. 263, no. 4 Pt 2, Oct. 1992, pp. R863–67. Pubmed, doi:10.1152/ajpregu.1992.263.4.R863.
Figlewicz DP, Nadzan AM, Sipols AJ, Green PK, Liddle RA, Porte D, Woods SC. Intraventricular CCK-8 reduces single meal size in the baboon by interaction with type-A CCK receptors. Am J Physiol. 1992 Oct;263(4 Pt 2):R863–R867.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

October 1992

Volume

263

Issue

4 Pt 2

Start / End Page

R863 / R867

Location

United States

Related Subject Headings

  • Tetragastrin
  • Sincalide
  • Receptors, Cholecystokinin
  • Papio
  • Oligopeptides
  • Male
  • Insulin
  • Injections, Intraventricular
  • Fasting
  • Eating