Potassium channels regulate cholecystokinin secretion in STC-1 cells.

Published

Journal Article

Following blockade of plasma membrane potassium channels with barium or tetraethylammonium chloride, release of cholecystokinin was increased in an intestinal cell line (STC-1). Treatment with calcium channel blockers inhibited barium- or TEA-induced secretion. Barium chloride also stimulated 45Ca efflux from STC-1 cells. Whole cell patch clamp recordings revealed a voltage-activated, L-type calcium current. We conclude that, inhibition of basally active potassium channels may depolarize STC-1 cells, producing activation of voltage-gated calcium influx pathways. Influx of calcium may lead to a release of intracellular calcium which stimulates cholecystokinin secretion.

Full Text

Duke Authors

Cited Authors

  • Snow, ND; Mangel, AW; Sharara, AI; Liddle, RA

Published Date

  • September 1, 1993

Published In

Volume / Issue

  • 195 / 3

Start / End Page

  • 1379 - 1385

PubMed ID

  • 8216272

Pubmed Central ID

  • 8216272

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1993.2196

Language

  • eng