Potassium channels regulate cholecystokinin secretion in STC-1 cells.
Publication
, Journal Article
Snow, ND; Mangel, AW; Sharara, AI; Liddle, RA
Published in: Biochem Biophys Res Commun
September 30, 1993
Following blockade of plasma membrane potassium channels with barium or tetraethylammonium chloride, release of cholecystokinin was increased in an intestinal cell line (STC-1). Treatment with calcium channel blockers inhibited barium- or TEA-induced secretion. Barium chloride also stimulated 45Ca efflux from STC-1 cells. Whole cell patch clamp recordings revealed a voltage-activated, L-type calcium current. We conclude that, inhibition of basally active potassium channels may depolarize STC-1 cells, producing activation of voltage-gated calcium influx pathways. Influx of calcium may lead to a release of intracellular calcium which stimulates cholecystokinin secretion.
Duke Scholars
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
September 30, 1993
Volume
195
Issue
3
Start / End Page
1379 / 1385
Location
United States
Related Subject Headings
- Tetraethylammonium Compounds
- Tetraethylammonium
- Potassium Channels
- Nicardipine
- Intestinal Mucosa
- Electric Conductivity
- Cholecystokinin
- Cell Line
- Calcium
- Biological Transport
Citation
APA
Chicago
ICMJE
MLA
NLM
Snow, N. D., Mangel, A. W., Sharara, A. I., & Liddle, R. A. (1993). Potassium channels regulate cholecystokinin secretion in STC-1 cells. Biochem Biophys Res Commun, 195(3), 1379–1385. https://doi.org/10.1006/bbrc.1993.2196
Snow, N. D., A. W. Mangel, A. I. Sharara, and R. A. Liddle. “Potassium channels regulate cholecystokinin secretion in STC-1 cells.” Biochem Biophys Res Commun 195, no. 3 (September 30, 1993): 1379–85. https://doi.org/10.1006/bbrc.1993.2196.
Snow ND, Mangel AW, Sharara AI, Liddle RA. Potassium channels regulate cholecystokinin secretion in STC-1 cells. Biochem Biophys Res Commun. 1993 Sep 30;195(3):1379–85.
Snow, N. D., et al. “Potassium channels regulate cholecystokinin secretion in STC-1 cells.” Biochem Biophys Res Commun, vol. 195, no. 3, Sept. 1993, pp. 1379–85. Pubmed, doi:10.1006/bbrc.1993.2196.
Snow ND, Mangel AW, Sharara AI, Liddle RA. Potassium channels regulate cholecystokinin secretion in STC-1 cells. Biochem Biophys Res Commun. 1993 Sep 30;195(3):1379–1385.
Published In
Biochem Biophys Res Commun
DOI
ISSN
0006-291X
Publication Date
September 30, 1993
Volume
195
Issue
3
Start / End Page
1379 / 1385
Location
United States
Related Subject Headings
- Tetraethylammonium Compounds
- Tetraethylammonium
- Potassium Channels
- Nicardipine
- Intestinal Mucosa
- Electric Conductivity
- Cholecystokinin
- Cell Line
- Calcium
- Biological Transport