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Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.

Publication ,  Journal Article
Basavappa, S; Liddle, RA; Mangel, AW
Published in: Biochem Biophys Res Commun
October 28, 1994

In the present study, the electrophysiologic properties of ATP-sensitive potassium channels were evaluated in an intestinal, cholecystokinin-secreting cell line (STC-1). Channels were operative under basal conditions and, in cell-attached membrane patches, channel activity was decreased by glucose or disopyramide, agents which classically inhibit ATP-sensitive potassium channels. Channel activity was increased by the KATP channel opener, diazoxide. Intestinal ATP-sensitive potassium channels appear to behave in a similar manner to those found in cardiac and pancreatic beta cells.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

October 28, 1994

Volume

204

Issue

2

Start / End Page

855 / 860

Location

United States

Related Subject Headings

  • Potassium Channels
  • Membrane Potentials
  • Intestinal Mucosa
  • Disopyramide
  • Cholecystokinin
  • Cells, Cultured
  • Biochemistry & Molecular Biology
  • Adenosine Triphosphate
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
 

Citation

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Basavappa, S., Liddle, R. A., & Mangel, A. W. (1994). Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells. Biochem Biophys Res Commun, 204(2), 855–860. https://doi.org/10.1006/bbrc.1994.2538
Basavappa, S., R. A. Liddle, and A. W. Mangel. “Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.Biochem Biophys Res Commun 204, no. 2 (October 28, 1994): 855–60. https://doi.org/10.1006/bbrc.1994.2538.
Basavappa S, Liddle RA, Mangel AW. Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells. Biochem Biophys Res Commun. 1994 Oct 28;204(2):855–60.
Basavappa, S., et al. “Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.Biochem Biophys Res Commun, vol. 204, no. 2, Oct. 1994, pp. 855–60. Pubmed, doi:10.1006/bbrc.1994.2538.
Basavappa S, Liddle RA, Mangel AW. Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells. Biochem Biophys Res Commun. 1994 Oct 28;204(2):855–860.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

October 28, 1994

Volume

204

Issue

2

Start / End Page

855 / 860

Location

United States

Related Subject Headings

  • Potassium Channels
  • Membrane Potentials
  • Intestinal Mucosa
  • Disopyramide
  • Cholecystokinin
  • Cells, Cultured
  • Biochemistry & Molecular Biology
  • Adenosine Triphosphate
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology