Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.

Journal Article (Journal Article)

In the present study, the electrophysiologic properties of ATP-sensitive potassium channels were evaluated in an intestinal, cholecystokinin-secreting cell line (STC-1). Channels were operative under basal conditions and, in cell-attached membrane patches, channel activity was decreased by glucose or disopyramide, agents which classically inhibit ATP-sensitive potassium channels. Channel activity was increased by the KATP channel opener, diazoxide. Intestinal ATP-sensitive potassium channels appear to behave in a similar manner to those found in cardiac and pancreatic beta cells.

Full Text

Duke Authors

Cited Authors

  • Basavappa, S; Liddle, RA; Mangel, AW

Published Date

  • October 28, 1994

Published In

Volume / Issue

  • 204 / 2

Start / End Page

  • 855 - 860

PubMed ID

  • 7980553

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1994.2538


  • eng

Conference Location

  • United States