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Pseudoanaplastic giant cell tumor of bone.

Publication ,  Journal Article
Layfield, LJ; Bentley, RC; Mirra, JM
Published in: Arch Pathol Lab Med
February 1999

Marked nuclear atypia can be found in a variety of benign mesenchymal tumors, including ancient schwannomas, symplastic leiomyomas, osteoblastomas, and chondromyxoid fibromas. Such nuclear atypia is believed to represent a degenerative phenomenon and does not indicate aggressive behavior. Separation of these pleomorphic but benign lesions from true sarcomas may be difficult. We are aware of only one prior description of such degenerative atypia in benign giant cell tumor of bone. We report a benign giant cell tumor of bone arising in the sacrum of a 21-year-old white female. Preoperative embolization of this lesion had been performed, and subsequent curetting revealed marked atypia suggestive of an anaplastic malignancy. However, only very rare mitotic figures were present, and the radiographs were consistent with a benign giant cell tumor. A diagnosis of benign giant cell tumor was made, and no recurrence or metastases have been observed during the 4-year postoperative period.

Duke Scholars

Published In

Arch Pathol Lab Med

DOI

ISSN

0003-9985

Publication Date

February 1999

Volume

123

Issue

2

Start / End Page

163 / 166

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Pathology
  • Humans
  • Giant Cell Tumor of Bone
  • Female
  • Bone Neoplasms
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Layfield, L. J., Bentley, R. C., & Mirra, J. M. (1999). Pseudoanaplastic giant cell tumor of bone. Arch Pathol Lab Med, 123(2), 163–166. https://doi.org/10.5858/1999-123-0163-PGCTOB
Layfield, L. J., R. C. Bentley, and J. M. Mirra. “Pseudoanaplastic giant cell tumor of bone.Arch Pathol Lab Med 123, no. 2 (February 1999): 163–66. https://doi.org/10.5858/1999-123-0163-PGCTOB.
Layfield LJ, Bentley RC, Mirra JM. Pseudoanaplastic giant cell tumor of bone. Arch Pathol Lab Med. 1999 Feb;123(2):163–6.
Layfield, L. J., et al. “Pseudoanaplastic giant cell tumor of bone.Arch Pathol Lab Med, vol. 123, no. 2, Feb. 1999, pp. 163–66. Pubmed, doi:10.5858/1999-123-0163-PGCTOB.
Layfield LJ, Bentley RC, Mirra JM. Pseudoanaplastic giant cell tumor of bone. Arch Pathol Lab Med. 1999 Feb;123(2):163–166.

Published In

Arch Pathol Lab Med

DOI

ISSN

0003-9985

Publication Date

February 1999

Volume

123

Issue

2

Start / End Page

163 / 166

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Pathology
  • Humans
  • Giant Cell Tumor of Bone
  • Female
  • Bone Neoplasms
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences