Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids.

Journal Article (Journal Article)

The mode of expression of novel HLA-DR antigens on hybrids of human T and B lymphoblastoid cell lines (LCL) was examined by several approaches. In each case, the results indicated that the novel antigens are T-LCL-encoded. First, hybrids of sublines of the T-LCL CEM with three different B-LCL express indistinguishable sets of novel HLA-DR antigens. Second, the novel HLA-DR and MT specificities of WI-L2 x HSB (a hybrid of a subline of the T-LCL HSB and the B-LCL WI-L2) match those of SB, a B-LCL derived from the same individual as HSB. Finally, an immunoselected variant of SB x CEM.1 (a hybrid of a subline of CEM and SB) lacking one copy of chromosome 6 and one of the hybrid's novel HLA-DR specificities also lacks a class I antigen known to be encoded by CEM.

Full Text

Duke Authors

Cited Authors

  • Howell, DN; Cresswell, P

Published Date

  • 1983

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 411 - 425

PubMed ID

  • 6601057

International Standard Serial Number (ISSN)

  • 0093-7711

Digital Object Identifier (DOI)

  • 10.1007/BF00372459


  • eng

Conference Location

  • United States