Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids.
Journal Article (Journal Article)
The Ia-like antigens of hybrids of the B-lymphoblastoid cell line (B-LCL) WI-L2 and a subline of the T-lymphoblastoid cell line (T-LCL) HSB were examined. Antigens of the HLA-DR and MT series were analyzed by indirect immunofluorescence with chimpanzee anti-DR sera and monoclonal antibodies, and antigens of the SB series were analyzed by primed lymphocyte typing (PLT). The WI-L2 X HSB hybrids expressed antigens of each series not found on either parent cell. In each case, the novel antigens were indistinguishable from those found on SB, a B-LCL established from the same individual as HSB, and are thus presumably HSB encoded.
Full Text
Duke Authors
Cited Authors
- Howell, DN; Hartzman, RJ; Cresswell, P
Published Date
- October 1, 1983
Published In
Volume / Issue
- 8 / 2
Start / End Page
- 167 - 175
PubMed ID
- 6417070
International Standard Serial Number (ISSN)
- 0198-8859
Digital Object Identifier (DOI)
- 10.1016/0198-8859(83)90011-3
Language
- eng
Conference Location
- United States