Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids.

Published

Journal Article

The Ia-like antigens of hybrids of the B-lymphoblastoid cell line (B-LCL) WI-L2 and a subline of the T-lymphoblastoid cell line (T-LCL) HSB were examined. Antigens of the HLA-DR and MT series were analyzed by indirect immunofluorescence with chimpanzee anti-DR sera and monoclonal antibodies, and antigens of the SB series were analyzed by primed lymphocyte typing (PLT). The WI-L2 X HSB hybrids expressed antigens of each series not found on either parent cell. In each case, the novel antigens were indistinguishable from those found on SB, a B-LCL established from the same individual as HSB, and are thus presumably HSB encoded.

Full Text

Duke Authors

Cited Authors

  • Howell, DN; Hartzman, RJ; Cresswell, P

Published Date

  • October 1, 1983

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 167 - 175

PubMed ID

  • 6417070

Pubmed Central ID

  • 6417070

International Standard Serial Number (ISSN)

  • 0198-8859

Language

  • eng

Conference Location

  • United States