Identification of viral infection by confocal microscopy.

Journal Article (Journal Article)

Confocal microscopy is a valuable adjunct to electron microscopy in the fields of diagnostic and investigative virology. Confocal imaging can be used to examine large amounts of tissue stained by a variety of methods for evidence of viral infection. Areas thus identified can then be processed for ultrastructural study, allowing a highly focused search for viral pathogens. With the possible exception of the vibrating microtome, all of the equipment and reagents necessary for the preparation of specimens for confocal scanning are available in any well-stocked histology laboratory. Although originally developed to facilitate viral diagnosis by EM, the methods described herein can be applied to the ultrastructural study of any focal pathologic process.

Full Text

Duke Authors

Cited Authors

  • Howell, DN; Miller, SE

Published Date

  • 1999

Published In

Volume / Issue

  • 307 /

Start / End Page

  • 573 - 591

PubMed ID

  • 10506995

International Standard Serial Number (ISSN)

  • 0076-6879

Digital Object Identifier (DOI)

  • 10.1016/s0076-6879(99)07034-2


  • eng

Conference Location

  • United States