Influence of berberine sulfate on synthesis and expression of Pap fimbrial adhesin in uropathogenic Escherichia coli.

Published

Journal Article

We investigated the influence of berberine sulfate, an ancient Chinese antibiotic, upon the adhesion of uropathogenic Escherichia coli to erythrocytes and epithelial cells. Although berberine sulfate in increasing concentrations had no effect on bacterial growth or on the synthesis of major outer membrane proteins of the E. coli organisms, it increasingly blocked adhesion. The decreased adhesion was accompanied by a reduction in the synthesis of fimbrial subunits and in the expression of assembled fimbriae. These results suggest that the anti-infectious activity of berberine sulfate in E. coli-induced urinary tract infections may be mediated by the selective suppression of the synthesis and assembly of fimbriae by uropathogenic organisms.

Full Text

Duke Authors

Cited Authors

  • Sun, D; Abraham, SN; Beachey, EH

Published Date

  • August 1988

Published In

Volume / Issue

  • 32 / 8

Start / End Page

  • 1274 - 1277

PubMed ID

  • 2903716

Pubmed Central ID

  • 2903716

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/aac.32.8.1274

Language

  • eng

Conference Location

  • United States