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Bacterial adherence. Adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces.

Publication ,  Journal Article
Beachey, EH; Giampapa, CS; Abraham, SN
Published in: Am Rev Respir Dis
December 1988

Pathogenic bacteria adhere to and colonize mucosal surfaces of the susceptible host in a highly selective manner. After the organisms penetrate the nonspecific mechanical and cleansing forces, ligands (or adhesins) on the surface of the bacteria interact in a lock-and-key fashion with complementary receptors on mucosal surfaces of the host. The adhesins are usually composed of proteins in the form of fimbriae or fibrillae and the receptors of glycolipids or glycoproteins. At the epithelial cell surfaces, two classic examples of bacterial adherence are the lipoteichoic acid-mediated attachments of group A streptococcal and the type 1 fimbriae-mediated attachment of Escherichia coli. In group A streptococci, the adhesin, lipoteichoic acid (LTA), is anchored to a protein(s) on the surface of the bacterial cells and interacts through its lipid moiety with fibronectin molecules deposited on and bound to the epithelial cells. In type 1 fimbriated E. coli, a minor 29-kDa protein located at the tip of the fimbriae interacts with D-mannose residues of glycoprotein receptors on host cells. Similar adhesin-receptor interactions have now been described for a number of pathogenic microbial agents, and undoubtedly play a central role in the early steps of the infectious process.

Duke Scholars

Published In

Am Rev Respir Dis

DOI

ISSN

0003-0805

Publication Date

December 1988

Volume

138

Issue

6 Pt 2

Start / End Page

S45 / S48

Location

United States

Related Subject Headings

  • Fimbriae, Bacterial
  • Escherichia coli
  • Bacterial Adhesion
 

Citation

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Chicago
ICMJE
MLA
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Beachey, E. H., Giampapa, C. S., & Abraham, S. N. (1988). Bacterial adherence. Adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces. Am Rev Respir Dis, 138(6 Pt 2), S45–S48. https://doi.org/10.1164/ajrccm/138.6_Pt_2.S45
Beachey, E. H., C. S. Giampapa, and S. N. Abraham. “Bacterial adherence. Adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces.Am Rev Respir Dis 138, no. 6 Pt 2 (December 1988): S45–48. https://doi.org/10.1164/ajrccm/138.6_Pt_2.S45.
Beachey EH, Giampapa CS, Abraham SN. Bacterial adherence. Adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces. Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S45–8.
Beachey, E. H., et al. “Bacterial adherence. Adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces.Am Rev Respir Dis, vol. 138, no. 6 Pt 2, Dec. 1988, pp. S45–48. Pubmed, doi:10.1164/ajrccm/138.6_Pt_2.S45.
Beachey EH, Giampapa CS, Abraham SN. Bacterial adherence. Adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces. Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S45–S48.

Published In

Am Rev Respir Dis

DOI

ISSN

0003-0805

Publication Date

December 1988

Volume

138

Issue

6 Pt 2

Start / End Page

S45 / S48

Location

United States

Related Subject Headings

  • Fimbriae, Bacterial
  • Escherichia coli
  • Bacterial Adhesion