Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.
Publication
, Journal Article
Arock, M; Ross, E; Lai-Kuen, R; Averlant, G; Gao, Z; Abraham, SN
Published in: Infect Immun
December 1998
Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.
Duke Scholars
Published In
Infect Immun
DOI
ISSN
0019-9567
Publication Date
December 1998
Volume
66
Issue
12
Start / End Page
6030 / 6034
Location
United States
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Pseudopodia
- Phagocytosis
- Microbiology
- Mast Cells
- Humans
- Gram-Positive Bacteria
- Gram-Negative Bacteria
- 3207 Medical microbiology
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Arock, M., Ross, E., Lai-Kuen, R., Averlant, G., Gao, Z., & Abraham, S. N. (1998). Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. Infect Immun, 66(12), 6030–6034. https://doi.org/10.1128/IAI.66.12.6030-6034.1998
Arock, M., E. Ross, R. Lai-Kuen, G. Averlant, Z. Gao, and S. N. Abraham. “Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.” Infect Immun 66, no. 12 (December 1998): 6030–34. https://doi.org/10.1128/IAI.66.12.6030-6034.1998.
Arock M, Ross E, Lai-Kuen R, Averlant G, Gao Z, Abraham SN. Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. Infect Immun. 1998 Dec;66(12):6030–4.
Arock, M., et al. “Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.” Infect Immun, vol. 66, no. 12, Dec. 1998, pp. 6030–34. Pubmed, doi:10.1128/IAI.66.12.6030-6034.1998.
Arock M, Ross E, Lai-Kuen R, Averlant G, Gao Z, Abraham SN. Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. Infect Immun. 1998 Dec;66(12):6030–6034.
Published In
Infect Immun
DOI
ISSN
0019-9567
Publication Date
December 1998
Volume
66
Issue
12
Start / End Page
6030 / 6034
Location
United States
Related Subject Headings
- Tumor Necrosis Factor-alpha
- Pseudopodia
- Phagocytosis
- Microbiology
- Mast Cells
- Humans
- Gram-Positive Bacteria
- Gram-Negative Bacteria
- 3207 Medical microbiology
- 3204 Immunology