Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.

Journal Article (Journal Article)

Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.

Full Text

Duke Authors

Cited Authors

  • Arock, M; Ross, E; Lai-Kuen, R; Averlant, G; Gao, Z; Abraham, SN

Published Date

  • December 1998

Published In

Volume / Issue

  • 66 / 12

Start / End Page

  • 6030 - 6034

PubMed ID

  • 9826392

Pubmed Central ID

  • PMC108768

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/IAI.66.12.6030-6034.1998


  • eng

Conference Location

  • United States