Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.
Journal Article (Journal Article)
Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.
Full Text
Duke Authors
Cited Authors
- Arock, M; Ross, E; Lai-Kuen, R; Averlant, G; Gao, Z; Abraham, SN
Published Date
- December 1998
Published In
Volume / Issue
- 66 / 12
Start / End Page
- 6030 - 6034
PubMed ID
- 9826392
Pubmed Central ID
- PMC108768
International Standard Serial Number (ISSN)
- 0019-9567
Digital Object Identifier (DOI)
- 10.1128/IAI.66.12.6030-6034.1998
Language
- eng
Conference Location
- United States