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Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.

Publication ,  Journal Article
Arock, M; Ross, E; Lai-Kuen, R; Averlant, G; Gao, Z; Abraham, SN
Published in: Infect Immun
December 1998

Recent studies have implicated rodent mast cells in the innate immune response to infectious bacteria. We report that cord blood-derived human mast cells (CBHMC) obtained from culture of cord blood progenitors phagocytozed and killed various gram-negative and gram-positive bacteria and simultaneously released considerable amounts of tumor necrosis factor alpha. Overall, the extent of the endocytic and exocytic response of CBHMC correlated with the number of adherent bacteria. Thus, human mast cells are intrinsically capable of mediating microbial recognition and of actively contributing to the host defense against bacteria.

Duke Scholars

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

December 1998

Volume

66

Issue

12

Start / End Page

6030 / 6034

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Pseudopodia
  • Phagocytosis
  • Microbiology
  • Mast Cells
  • Humans
  • Gram-Positive Bacteria
  • Gram-Negative Bacteria
  • 3207 Medical microbiology
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Arock, M., Ross, E., Lai-Kuen, R., Averlant, G., Gao, Z., & Abraham, S. N. (1998). Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. Infect Immun, 66(12), 6030–6034. https://doi.org/10.1128/IAI.66.12.6030-6034.1998
Arock, M., E. Ross, R. Lai-Kuen, G. Averlant, Z. Gao, and S. N. Abraham. “Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.Infect Immun 66, no. 12 (December 1998): 6030–34. https://doi.org/10.1128/IAI.66.12.6030-6034.1998.
Arock M, Ross E, Lai-Kuen R, Averlant G, Gao Z, Abraham SN. Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. Infect Immun. 1998 Dec;66(12):6030–4.
Arock, M., et al. “Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria.Infect Immun, vol. 66, no. 12, Dec. 1998, pp. 6030–34. Pubmed, doi:10.1128/IAI.66.12.6030-6034.1998.
Arock M, Ross E, Lai-Kuen R, Averlant G, Gao Z, Abraham SN. Phagocytic and tumor necrosis factor alpha response of human mast cells following exposure to gram-negative and gram-positive bacteria. Infect Immun. 1998 Dec;66(12):6030–6034.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

December 1998

Volume

66

Issue

12

Start / End Page

6030 / 6034

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Pseudopodia
  • Phagocytosis
  • Microbiology
  • Mast Cells
  • Humans
  • Gram-Positive Bacteria
  • Gram-Negative Bacteria
  • 3207 Medical microbiology
  • 3204 Immunology