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Involvement of cellular caveolae in bacterial entry into mast cells.

Publication ,  Journal Article
Shin, JS; Gao, Z; Abraham, SN
Published in: Science
August 4, 2000

Caveolae are subcellular structures implicated in the import and transcytosis of macromolecules and in transmembrane signaling. To date, evidence for the existence of caveolae in hematopoietic cells has been ambiguous. Caveolae were detected in the microvilli and intracellular vesicles of cultured mouse bone marrow-derived mast cells (BMMCs). CD48, a receptor for FimH-expressing (type 1 fimbriated) Escherichia coli, was specifically localized to plasmalemmal caveolae in BMMCs. The involvement of caveolae in bacterial entry into BMMCs was indicated because caveolae-disrupting and -usurping agents specifically blocked E. coli entry, and markers of caveolae were actively recruited to sites of bacterial entry. The formation of bacteria-encapsulating caveolar chambers in BMMCs represents a distinct mechanism of microbial entry into phagocytes.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

August 4, 2000

Volume

289

Issue

5480

Start / End Page

785 / 788

Location

United States

Related Subject Headings

  • Microscopy, Immunoelectron
  • Microscopy, Fluorescence
  • Microscopy, Confocal
  • Mice
  • Membrane Proteins
  • Mast Cells
  • Glycosylphosphatidylinositols
  • General Science & Technology
  • Fimbriae Proteins
  • Escherichia coli
 

Citation

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Shin, J. S., Gao, Z., & Abraham, S. N. (2000). Involvement of cellular caveolae in bacterial entry into mast cells. Science, 289(5480), 785–788. https://doi.org/10.1126/science.289.5480.785
Shin, J. S., Z. Gao, and S. N. Abraham. “Involvement of cellular caveolae in bacterial entry into mast cells.Science 289, no. 5480 (August 4, 2000): 785–88. https://doi.org/10.1126/science.289.5480.785.
Shin JS, Gao Z, Abraham SN. Involvement of cellular caveolae in bacterial entry into mast cells. Science. 2000 Aug 4;289(5480):785–8.
Shin, J. S., et al. “Involvement of cellular caveolae in bacterial entry into mast cells.Science, vol. 289, no. 5480, Aug. 2000, pp. 785–88. Pubmed, doi:10.1126/science.289.5480.785.
Shin JS, Gao Z, Abraham SN. Involvement of cellular caveolae in bacterial entry into mast cells. Science. 2000 Aug 4;289(5480):785–788.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

August 4, 2000

Volume

289

Issue

5480

Start / End Page

785 / 788

Location

United States

Related Subject Headings

  • Microscopy, Immunoelectron
  • Microscopy, Fluorescence
  • Microscopy, Confocal
  • Mice
  • Membrane Proteins
  • Mast Cells
  • Glycosylphosphatidylinositols
  • General Science & Technology
  • Fimbriae Proteins
  • Escherichia coli