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Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48.

Publication ,  Journal Article
Muñoz, S; Hernández-Pando, R; Abraham, SN; Enciso, JA
Published in: J Immunol
June 1, 2003

Mast cells (MC) are abundant in the lung and other peripheral tissue, where they participate in inflammatory processes against bacterial infections. Like other effector cells of the innate immune system, MC interact directly with a wide variety of infectious agents. This interaction results in MC activation and inflammatory mediator release. We demonstrated that MC interact with Mycobacterium tuberculosis, triggering the release of several prestored reagents, such as histamine and beta-hexosaminidase, and de novo synthesized cytokines, such as TNF-alpha and IL-6. A number of M. tuberculosis Ags, ESAT-6, MTSA-10, and MPT-63, have been implicated in MC activation and mediator release. A MC plasmalemmal protein, CD48, was implicated in interactions with mycobacteria because CD48 appeared to aggregate in the MC membrane at sites of bacterial binding and because Abs to CD48 inhibited the MC histamine response to mycobacteria. Cumulatively, these findings suggest that MC, even in the absence of opsonins, can directly recognize M. tuberculosis and its Ags and have the potential to play an active role in mediating the host's innate response to M. tuberculosis infection.

Duke Scholars

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

June 1, 2003

Volume

170

Issue

11

Start / End Page

5590 / 5596

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Mycobacterium tuberculosis
  • Microscopy, Immunoelectron
  • Microscopy, Confocal
  • Membrane Microdomains
  • Mast Cells
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Muñoz, S., Hernández-Pando, R., Abraham, S. N., & Enciso, J. A. (2003). Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. J Immunol, 170(11), 5590–5596. https://doi.org/10.4049/jimmunol.170.11.5590
Muñoz, Samira, Rogelio Hernández-Pando, Soman N. Abraham, and Jose Antonio Enciso. “Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48.J Immunol 170, no. 11 (June 1, 2003): 5590–96. https://doi.org/10.4049/jimmunol.170.11.5590.
Muñoz S, Hernández-Pando R, Abraham SN, Enciso JA. Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. J Immunol. 2003 Jun 1;170(11):5590–6.
Muñoz, Samira, et al. “Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48.J Immunol, vol. 170, no. 11, June 2003, pp. 5590–96. Pubmed, doi:10.4049/jimmunol.170.11.5590.
Muñoz S, Hernández-Pando R, Abraham SN, Enciso JA. Mast cell activation by Mycobacterium tuberculosis: mediator release and role of CD48. J Immunol. 2003 Jun 1;170(11):5590–5596.

Published In

J Immunol

DOI

ISSN

0022-1767

Publication Date

June 1, 2003

Volume

170

Issue

11

Start / End Page

5590 / 5596

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Mycobacterium tuberculosis
  • Microscopy, Immunoelectron
  • Microscopy, Confocal
  • Membrane Microdomains
  • Mast Cells
  • Male