Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis.

Journal Article (Review)

An increasing number of pathogens or their toxins appear to utilize glycosylphosphatidylinositol(GPI)-anchored receptors to trigger entry into immune and other host cells. Since these receptors have no transmembrane and intracellular moieties, how endocytosis is initiated is unclear. Recently, CD48 on mast cell membranes was shown to trigger endocytosis of bacteria via a route that avoids fusion with lysosomes and by a mechanism involving discrete cellular entities called caveolae. The localization of CD48 within caveolae appears to be a prerequisite for caveolae-mediated bacterial entry.

Full Text

Duke Authors

Cited Authors

  • Shin, JS; Abraham, SN

Published Date

  • April 13, 2001

Published In

Volume / Issue

  • 197 / 2

Start / End Page

  • 131 - 138

PubMed ID

  • 11313125

Pubmed Central ID

  • 11313125

International Standard Serial Number (ISSN)

  • 0378-1097

Digital Object Identifier (DOI)

  • 10.1111/j.1574-6968.2001.tb10594.x


  • eng

Conference Location

  • England