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Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.

Publication ,  Journal Article
Mielcarek, N; Hörnquist, EH; Johansson, BR; Locht, C; Abraham, SN; Holmgren, J
Published in: Cell Microbiol
March 2001

Together with macrophages and dendritic cells, mast cells have recently been shown to interact with certain pathogenic bacteria and present microbial antigens to the immune system. We show here that Bordetella pertussis can adhere to and be phagocytosed by mast cells. In addition, mast cells are able to process and present B. pertussis antigens to T lymphocytes. Furthermore, exposure of mast cells to B. pertussis induced the release of the proinflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6). The release of IL-6 was strongly reduced by pertussis toxin expressed by B. pertussis. The production of IL-10, but not that of IL-4, by mast cells was also inhibited by pertussis toxin. Depletion of mast cells in vivo resulted in significant reduction of early TNF-alpha production in bronchoalveolar lavage (BAL) fluids of B. pertussis-infected mice. These data suggest that mast cells may play a role in the induction of immune responses against B. pertussis through the release of cytokines, especially TNF-alpha.

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Published In

Cell Microbiol

DOI

ISSN

1462-5814

Publication Date

March 2001

Volume

3

Issue

3

Start / End Page

181 / 188

Location

India

Related Subject Headings

  • Whooping Cough
  • Virulence Factors, Bordetella
  • Tumor Necrosis Factor-alpha
  • T-Lymphocytes
  • Phagocytosis
  • Pertussis Toxin
  • Microbiology
  • Mice, Inbred C57BL
  • Mice
  • Mast Cells
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mielcarek, N., Hörnquist, E. H., Johansson, B. R., Locht, C., Abraham, S. N., & Holmgren, J. (2001). Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. Cell Microbiol, 3(3), 181–188. https://doi.org/10.1046/j.1462-5822.2001.00106.x
Mielcarek, N., E. H. Hörnquist, B. R. Johansson, C. Locht, S. N. Abraham, and J. Holmgren. “Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.Cell Microbiol 3, no. 3 (March 2001): 181–88. https://doi.org/10.1046/j.1462-5822.2001.00106.x.
Mielcarek N, Hörnquist EH, Johansson BR, Locht C, Abraham SN, Holmgren J. Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. Cell Microbiol. 2001 Mar;3(3):181–8.
Mielcarek, N., et al. “Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.Cell Microbiol, vol. 3, no. 3, Mar. 2001, pp. 181–88. Pubmed, doi:10.1046/j.1462-5822.2001.00106.x.
Mielcarek N, Hörnquist EH, Johansson BR, Locht C, Abraham SN, Holmgren J. Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. Cell Microbiol. 2001 Mar;3(3):181–188.
Journal cover image

Published In

Cell Microbiol

DOI

ISSN

1462-5814

Publication Date

March 2001

Volume

3

Issue

3

Start / End Page

181 / 188

Location

India

Related Subject Headings

  • Whooping Cough
  • Virulence Factors, Bordetella
  • Tumor Necrosis Factor-alpha
  • T-Lymphocytes
  • Phagocytosis
  • Pertussis Toxin
  • Microbiology
  • Mice, Inbred C57BL
  • Mice
  • Mast Cells