Mast cell modulation of immune responses to bacteria.

Journal Article (Journal Article;Review)

Mast cells are key elements of the immune system. These cells release a wide variety of pro-inflammatory mediators which are responsible for the pathophysiology of many allergic diseases. Recent studies, however, have shown that mast cells have the capacity to modulate the host's innate immune response to gram negative bacteria by their ability to phagocytose bacteria, process and present bacterial antigens to T cells and recruit phagocytic help through the release of physiological amounts of pro-inflammatory mediators. Here, current knowledge of mast cell responses to gram negative bacteria and molecular mechanisms associated with mast cell bacteria interaction is reviewed.

Full Text

Duke Authors

Cited Authors

  • Malaviya, R; Abraham, SN

Published Date

  • February 2001

Published In

Volume / Issue

  • 179 /

Start / End Page

  • 16 - 24

PubMed ID

  • 11292019

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1034/j.1600-065x.2001.790102.x


  • eng

Conference Location

  • England