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Evolutionary rate variation in anthocyanin pathway genes.

Publication ,  Journal Article
Lu, Y; Rausher, MD
Published in: Molecular biology and evolution
November 2003

Over a broad taxonomic range that spans monocots and dicots, upstream enzymes of the anthocyanin pigment pathway have evolved less rapidly than downstream enzymes. In this article we show that this pattern is also evident within the genus Ipomoea. Specifically, the most upstream enzyme, chalcone synthase (CHS-D), evolves more slowly than the two most downstream enzymes, ancyocyanidin synthase (ANS) and UDP glucose flavonoid 3-oxy-glucosyltransferase (UFGT). This pattern appears not to be due to variation in mutation rates, because the CHS-D gene exhibits higher synonymous substitution rates than the genes for the other two enzymes. Codon-based tests for positive selection suggest that it has been negligible or absent in all three genes. In addition, the mean number of indel-creating events is four times as high in the downstream genes as in CHS-D. Unlike the downstream genes, CHS-D also exhibits evidence of codon bias. Together, the evidence suggests that the difference in nonsynonymous substitution rates between upstream and downstream genes is due to relaxed constraint on the downstream genes rather than a greater frequency of positively selected substitutions.

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Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

November 2003

Volume

20

Issue

11

Start / End Page

1844 / 1853

Related Subject Headings

  • Time Factors
  • Phylogeny
  • Oxygenases
  • Mutation
  • Models, Statistical
  • Models, Genetic
  • Likelihood Functions
  • Ipomoea
  • Glucosyltransferases
  • Evolutionary Biology
 

Citation

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MLA
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Lu, Y., & Rausher, M. D. (2003). Evolutionary rate variation in anthocyanin pathway genes. Molecular Biology and Evolution, 20(11), 1844–1853. https://doi.org/10.1093/molbev/msg197
Lu, Yingqing, and Mark D. Rausher. “Evolutionary rate variation in anthocyanin pathway genes.Molecular Biology and Evolution 20, no. 11 (November 2003): 1844–53. https://doi.org/10.1093/molbev/msg197.
Lu Y, Rausher MD. Evolutionary rate variation in anthocyanin pathway genes. Molecular biology and evolution. 2003 Nov;20(11):1844–53.
Lu, Yingqing, and Mark D. Rausher. “Evolutionary rate variation in anthocyanin pathway genes.Molecular Biology and Evolution, vol. 20, no. 11, Nov. 2003, pp. 1844–53. Epmc, doi:10.1093/molbev/msg197.
Lu Y, Rausher MD. Evolutionary rate variation in anthocyanin pathway genes. Molecular biology and evolution. 2003 Nov;20(11):1844–1853.
Journal cover image

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

November 2003

Volume

20

Issue

11

Start / End Page

1844 / 1853

Related Subject Headings

  • Time Factors
  • Phylogeny
  • Oxygenases
  • Mutation
  • Models, Statistical
  • Models, Genetic
  • Likelihood Functions
  • Ipomoea
  • Glucosyltransferases
  • Evolutionary Biology