Early-onset Alzheimer's disease: clinical predictors of institutionalization and death.


Journal Article

Follow-up observations were made of 92 white patients with early-onset Alzheimer's disease to determine the demographic, clinical, and neuropsychological factors predictive of institutionalization or death. The cumulative mortality rate 5 years after entry into the study was 23.9%, compared with an expected rate of 9.5%. The 5-year cumulative rate of admission to nursing homes was 62.8%. The language ability of the patients on entry to the study, their scores on a brief screening test of cognitive function, and their overall ratings of clinical dementia were found to be predictors of subsequent institutional care and death. The age of the patients had a significant modifying effect on these predictive factors, resulting in a greater risk of institutionalization and death in younger patients with severe cognitive impairment as compared with older individuals with the same degree of dysfunction.

Full Text

Duke Authors

Cited Authors

  • Heyman, A; Wilkinson, WE; Hurwitz, BJ; Helms, MJ; Haynes, CS; Utley, CM; Gwyther, LP

Published Date

  • June 1, 1987

Published In

Volume / Issue

  • 37 / 6

Start / End Page

  • 980 - 984

PubMed ID

  • 3587649

Pubmed Central ID

  • 3587649

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.37.6.980


  • eng

Conference Location

  • United States