Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.
Publication
, Journal Article
Berman, HK; Newgard, CB
Published in: Biochemistry
March 31, 1998
Adenovirus-mediated overexpression of the glucose phosphorylating enzyme glucokinase causes large changes in glycolytic flux and glucose storage in isolated rat hepatocytes, but not in pancreatic islets. We have used the well-differentiated insulinoma cell line INS-1 to investigate the basis for these apparent cell-type specific differences. We find that 2- or 5-[3H]glucose usage is increased at low (
Duke Scholars
Published In
Biochemistry
DOI
ISSN
0006-2960
Publication Date
March 31, 1998
Volume
37
Issue
13
Start / End Page
4543 / 4552
Location
United States
Related Subject Headings
- Recombination, Genetic
- Rats, Wistar
- Rats
- Male
- Liver
- Lactic Acid
- L-Lactate Dehydrogenase
- Islets of Langerhans
- In Vitro Techniques
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Berman, H. K., & Newgard, C. B. (1998). Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. Biochemistry, 37(13), 4543–4552. https://doi.org/10.1021/bi9726133
Berman, H. K., and C. B. Newgard. “Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.” Biochemistry 37, no. 13 (March 31, 1998): 4543–52. https://doi.org/10.1021/bi9726133.
Berman HK, Newgard CB. Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. Biochemistry. 1998 Mar 31;37(13):4543–52.
Berman, H. K., and C. B. Newgard. “Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.” Biochemistry, vol. 37, no. 13, Mar. 1998, pp. 4543–52. Pubmed, doi:10.1021/bi9726133.
Berman HK, Newgard CB. Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression. Biochemistry. 1998 Mar 31;37(13):4543–4552.
Published In
Biochemistry
DOI
ISSN
0006-2960
Publication Date
March 31, 1998
Volume
37
Issue
13
Start / End Page
4543 / 4552
Location
United States
Related Subject Headings
- Recombination, Genetic
- Rats, Wistar
- Rats
- Male
- Liver
- Lactic Acid
- L-Lactate Dehydrogenase
- Islets of Langerhans
- In Vitro Techniques
- Humans