Protein synthesis. The perks of balancing glucose.

Journal Article (Journal Article)

What do the regulation of translation initiation and glucose metabolism have to do with each other? Quite a lot, it seems, according to Sonenberg and Newgard in their Perspective. They discuss new findings that identify the kinase responsible for inactivating eIF2--a factor that is required for translation initiation (and hence protein synthesis)--when the endoplasmic reticulum is under stress. Loss of this kinase results in destruction of insulin-producing b cells in the pancreas and dysregulation of glucose homeostasis.

Full Text

Duke Authors

Cited Authors

  • Sonenberg, N; Newgard, CB

Published Date

  • August 3, 2001

Published In

Volume / Issue

  • 293 / 5531

Start / End Page

  • 818 - 819

PubMed ID

  • 11486079

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1062937


  • eng

Conference Location

  • United States