A novel leptin receptor isoform in rat.

Published

Journal Article

Five mouse and human leptin receptors (Ob-R) have recently been identified, a long isoform (Ob-Rb), preferentially expressed in hypothalamus, and 4 short isoforms, Ob-Ra, Ob-Rc, Ob-Rd, and Ob-Re. We have identified a new short isoform in the rat, r-OB-Rf, with 6 C-terminal amino acids and a 3' untranslated region without homology to other Ob-R isoforms. Its higher expression in rat liver and spleen compared to brain, stomach, kidney, thymus, heart, lung and hypothalamus, contrasts with Ob-Ra and Ob-Rb homologues and raises possibilities of as yet unidentified roles for members of the growing Ob-R gene family.

Full Text

Duke Authors

Cited Authors

  • Wang, MY; Zhou, YT; Newgard, CB; Unger, RH

Published Date

  • August 26, 1996

Published In

Volume / Issue

  • 392 / 2

Start / End Page

  • 87 - 90

PubMed ID

  • 8772180

Pubmed Central ID

  • 8772180

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(96)00790-9

Language

  • eng

Conference Location

  • England