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[Insulin producing cells as therapy in diabetes mellitus].

Publication ,  Journal Article
Schnedl, WJ; Hohmeier, HE; Newgard, CB
Published in: Naturwissenschaften
January 1996

Even with intensive insulin therapy it is impossible to reach physiological blood glucose levels in insulin-dependent diabetes mellitus. Because of the high costs and technical problems involved in islet cell transplantation broad applicability of this therapy seems uncertain. An alternative approach is the development of molecular-engineered insulin-producing clonal cell lines. The main interest is in rodent insulinoma cell lines and neuroendocrine AtT-20ins cells. This paper reviews the current knowledge about glucose-stimulated insulin secretion and the problems that have to be solved before these cells can be used for therapy in diabetes mellitus.

Duke Scholars

Published In

Naturwissenschaften

ISSN

0028-1042

Publication Date

January 1996

Volume

83

Issue

1

Start / End Page

1 / 5

Location

Germany

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Recombinant Proteins
  • Rats, Nude
  • Rats
  • Pancreatic Neoplasms
  • Neoplasm Transplantation
  • Insulinoma
  • Insulin Secretion
  • Insulin
 

Citation

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ICMJE
MLA
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Schnedl, W. J., Hohmeier, H. E., & Newgard, C. B. (1996). [Insulin producing cells as therapy in diabetes mellitus]. Naturwissenschaften, 83(1), 1–5.
Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “[Insulin producing cells as therapy in diabetes mellitus].Naturwissenschaften 83, no. 1 (January 1996): 1–5.
Schnedl WJ, Hohmeier HE, Newgard CB. [Insulin producing cells as therapy in diabetes mellitus]. Naturwissenschaften. 1996 Jan;83(1):1–5.
Schnedl, W. J., et al. “[Insulin producing cells as therapy in diabetes mellitus].Naturwissenschaften, vol. 83, no. 1, Jan. 1996, pp. 1–5.
Schnedl WJ, Hohmeier HE, Newgard CB. [Insulin producing cells as therapy in diabetes mellitus]. Naturwissenschaften. 1996 Jan;83(1):1–5.
Journal cover image

Published In

Naturwissenschaften

ISSN

0028-1042

Publication Date

January 1996

Volume

83

Issue

1

Start / End Page

1 / 5

Location

Germany

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Recombinant Proteins
  • Rats, Nude
  • Rats
  • Pancreatic Neoplasms
  • Neoplasm Transplantation
  • Insulinoma
  • Insulin Secretion
  • Insulin