[Insulin producing cells as therapy in diabetes mellitus].
Publication
, Journal Article
Schnedl, WJ; Hohmeier, HE; Newgard, CB
Published in: Naturwissenschaften
January 1996
Even with intensive insulin therapy it is impossible to reach physiological blood glucose levels in insulin-dependent diabetes mellitus. Because of the high costs and technical problems involved in islet cell transplantation broad applicability of this therapy seems uncertain. An alternative approach is the development of molecular-engineered insulin-producing clonal cell lines. The main interest is in rodent insulinoma cell lines and neuroendocrine AtT-20ins cells. This paper reviews the current knowledge about glucose-stimulated insulin secretion and the problems that have to be solved before these cells can be used for therapy in diabetes mellitus.
Duke Scholars
Published In
Naturwissenschaften
ISSN
0028-1042
Publication Date
January 1996
Volume
83
Issue
1
Start / End Page
1 / 5
Location
Germany
Related Subject Headings
- Tumor Cells, Cultured
- Transfection
- Recombinant Proteins
- Rats, Nude
- Rats
- Pancreatic Neoplasms
- Neoplasm Transplantation
- Insulinoma
- Insulin Secretion
- Insulin
Citation
APA
Chicago
ICMJE
MLA
NLM
Schnedl, W. J., Hohmeier, H. E., & Newgard, C. B. (1996). [Insulin producing cells as therapy in diabetes mellitus]. Naturwissenschaften, 83(1), 1–5.
Schnedl, W. J., H. E. Hohmeier, and C. B. Newgard. “[Insulin producing cells as therapy in diabetes mellitus].” Naturwissenschaften 83, no. 1 (January 1996): 1–5.
Schnedl WJ, Hohmeier HE, Newgard CB. [Insulin producing cells as therapy in diabetes mellitus]. Naturwissenschaften. 1996 Jan;83(1):1–5.
Schnedl, W. J., et al. “[Insulin producing cells as therapy in diabetes mellitus].” Naturwissenschaften, vol. 83, no. 1, Jan. 1996, pp. 1–5.
Schnedl WJ, Hohmeier HE, Newgard CB. [Insulin producing cells as therapy in diabetes mellitus]. Naturwissenschaften. 1996 Jan;83(1):1–5.
Published In
Naturwissenschaften
ISSN
0028-1042
Publication Date
January 1996
Volume
83
Issue
1
Start / End Page
1 / 5
Location
Germany
Related Subject Headings
- Tumor Cells, Cultured
- Transfection
- Recombinant Proteins
- Rats, Nude
- Rats
- Pancreatic Neoplasms
- Neoplasm Transplantation
- Insulinoma
- Insulin Secretion
- Insulin