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Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.

Publication ,  Journal Article
Newgard, CB; Lu, D; Jensen, MV; Schissler, J; Boucher, A; Burgess, S; Sherry, AD
Published in: Diabetes
December 2002

There is a growing appreciation for the complexity of the pathways involved in glucose-stimulated insulin secretion (GSIS) from pancreatic islet beta-cells. In our laboratory, this has stimulated the development of an interdisciplinary approach to the problem. In this study, we review recent studies combining the tools of recombinant adenovirus for gene delivery, the development of novel cell lines that exhibit either robust or weak GSIS, and nuclear magnetic resonance imaging for metabolic fingerprinting of glucose-stimulated cells. Using these tools, we demonstrate a potentially important role for pyruvate carboxylase-mediated pyruvate cycling pathways in the control of GSIS, and discuss potential coupling factors produced by such pathways.

Duke Scholars

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Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

December 2002

Volume

51 Suppl 3

Start / End Page

S389 / S393

Location

United States

Related Subject Headings

  • Magnetic Resonance Spectroscopy
  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • Humans
  • Glucose
  • Gene Transfer Techniques
  • Endocrinology & Metabolism
  • Cell Line
  • Animals
 

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Newgard, C. B., Lu, D., Jensen, M. V., Schissler, J., Boucher, A., Burgess, S., & Sherry, A. D. (2002). Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes, 51 Suppl 3, S389–S393. https://doi.org/10.2337/diabetes.51.2007.s389
Newgard, Christopher B., Danhong Lu, Mette Valentin Jensen, Jonathan Schissler, Anne Boucher, Shawn Burgess, and A Dean Sherry. “Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.Diabetes 51 Suppl 3 (December 2002): S389–93. https://doi.org/10.2337/diabetes.51.2007.s389.
Newgard CB, Lu D, Jensen MV, Schissler J, Boucher A, Burgess S, et al. Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes. 2002 Dec;51 Suppl 3:S389–93.
Newgard, Christopher B., et al. “Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.Diabetes, vol. 51 Suppl 3, Dec. 2002, pp. S389–93. Pubmed, doi:10.2337/diabetes.51.2007.s389.
Newgard CB, Lu D, Jensen MV, Schissler J, Boucher A, Burgess S, Sherry AD. Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes. 2002 Dec;51 Suppl 3:S389–S393.

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

December 2002

Volume

51 Suppl 3

Start / End Page

S389 / S393

Location

United States

Related Subject Headings

  • Magnetic Resonance Spectroscopy
  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • Humans
  • Glucose
  • Gene Transfer Techniques
  • Endocrinology & Metabolism
  • Cell Line
  • Animals