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While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001.

Publication ,  Journal Article
Newgard, CB
Published in: Diabetes
November 2002

A common feature of the two major forms of human diabetes is the partial or complete loss of insulin secretion from beta-cells in the pancreatic islets of Langerhans. In this article, we review the development of a set of tools for studying beta-cell biology and their application to understanding of fuel-mediated insulin secretion and enhancement of beta-cell survival. Insights into these basic issues are likely to be useful for the design of new drug and cell-based diabetes therapies.

Duke Scholars

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

November 2002

Volume

51

Issue

11

Start / End Page

3141 / 3150

Location

United States

Related Subject Headings

  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • Humans
  • Homeostasis
  • Glucose
  • Energy Metabolism
  • Endocrinology & Metabolism
  • Animals
  • 32 Biomedical and clinical sciences
 

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

November 2002

Volume

51

Issue

11

Start / End Page

3141 / 3150

Location

United States

Related Subject Headings

  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • Humans
  • Homeostasis
  • Glucose
  • Energy Metabolism
  • Endocrinology & Metabolism
  • Animals
  • 32 Biomedical and clinical sciences