While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001.


Journal Article

A common feature of the two major forms of human diabetes is the partial or complete loss of insulin secretion from beta-cells in the pancreatic islets of Langerhans. In this article, we review the development of a set of tools for studying beta-cell biology and their application to understanding of fuel-mediated insulin secretion and enhancement of beta-cell survival. Insights into these basic issues are likely to be useful for the design of new drug and cell-based diabetes therapies.

Full Text

Duke Authors

Cited Authors

  • Newgard, CB

Published Date

  • November 2002

Published In

Volume / Issue

  • 51 / 11

Start / End Page

  • 3141 - 3150

PubMed ID

  • 12401704

Pubmed Central ID

  • 12401704

International Standard Serial Number (ISSN)

  • 0012-1797

Digital Object Identifier (DOI)

  • 10.2337/diabetes.51.11.3141


  • eng

Conference Location

  • United States