Techniques for long-term multisite neuronal ensemble recordings in behaving animals.

Journal Article (Review)

Advances in our understanding of neural systems will go hand in hand with improvements in the experimental techniques used to study these systems. This article describes a series of methodological developments aimed at enhancing the power of the methods needed to record simultaneously from populations of neurons over broad regions of the brain in awake, behaving animals. First, our laboratory has made many advances in electrode design, including movable bundle and array electrodes and smaller electrode assemblies. Second, to perform longer and more complex multielectrode implantation surgeries in primates, we have modified our surgical procedures by employing comprehensive physiological monitoring akin to human neuroanesthesia. We have also developed surgical implantation techniques aimed at minimizing brain tissue damage and facilitating penetration of the cortical surface. Third, we have integrated new technologies into our neural ensemble, stimulus and behavioral recording experiments to provide more detailed measurements of experimental variables. Finally, new data analytical techniques are being used in the laboratory to analyze increasingly large quantities of data.

Full Text

Duke Authors

Cited Authors

  • Kralik, JD; Dimitrov, DF; Krupa, DJ; Katz, DB; Cohen, D; Nicolelis, MA

Published Date

  • October 2001

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 121 - 150

PubMed ID

  • 11812202

International Standard Serial Number (ISSN)

  • 1046-2023

Digital Object Identifier (DOI)

  • 10.1006/meth.2001.1231

Language

  • eng

Conference Location

  • United States