Immediate thalamic sensory plasticity depends on corticothalamic feedback.

Published

Journal Article

Multiple neuron ensemble recordings were obtained simultaneously from both the primary somatosensory (SI) cortex and the ventroposterior medial thalamus (VPM) before and during the combined administration of reversible inactivation of the SI cortex and a reversible subcutaneous block of peripheral trigeminal nerve fibers. This procedure was performed to quantify the contribution of descending corticofugal projections on (i) the normal organization of thalamic somatosensory receptive fields and (ii) the thalamic somatosensory plastic reorganization that immediately follows a peripheral deafferentation. Reversible inactivation of SI cortex resulted in immediate changes in receptive field properties throughout the VPM. Cortical inactivation also significantly reduced but did not completely eliminate the occurrence of VPM receptive field reorganization resulting from the reversible peripheral deafferentation. This result suggests that the thalamic plasticity that is seen immediately after a peripheral deafferentation is dependent upon both descending corticofugal projections and ascending trigeminothalamic projections.

Full Text

Duke Authors

Cited Authors

  • Krupa, DJ; Ghazanfar, AA; Nicolelis, MA

Published Date

  • July 6, 1999

Published In

Volume / Issue

  • 96 / 14

Start / End Page

  • 8200 - 8205

PubMed ID

  • 10393972

Pubmed Central ID

  • 10393972

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.96.14.8200

Language

  • eng

Conference Location

  • United States