Time series analysis of rhythmic bacterial resistance development to antibiotics.

Journal Article (Journal Article)

The sensitivity data of Staphylococcus aureus and Escherichia coli to a large set of antibiotics have undergone time series procedures of analysis in order to highlight possibly periodical behavior in time. These oscillational patterns have been characterized through the use of FFT and cross-correlational and variance analysis and were proved to be species-specific and drug-independent. S. aureus was shown to have a large period of oscillation (40 months) when compared to E. coli (from 7 to 11 months). A perfect species distinction was only possible through cross correlation. These results may reflect the influence of the local environment, since this finding was not referred to in the literature.

Full Text

Duke Authors

Cited Authors

  • Nicolelis, MA; Baccala, LA

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 21 / 2

Start / End Page

  • 137 - 157

PubMed ID

  • 3286102

International Standard Serial Number (ISSN)

  • 0010-4809

Digital Object Identifier (DOI)

  • 10.1016/0010-4809(88)90022-5


  • eng

Conference Location

  • United States