Scholars@Duke publication: Chronic, multisite, multielectrode recordings in macaque monkeys.

Chronic, multisite, multielectrode recordings in macaque monkeys.

Publication , Journal Article

Nicolelis, MAL; Dimitrov, D; Carmena, JM; Crist, R; Lehew, G; Kralik, JD; Wise, SP

Published in: Proc Natl Acad Sci U S A

September 16, 2003

A paradigm is described for recording the activity of single cortical neurons from awake, behaving macaque monkeys. Its unique features include high-density microwire arrays and multichannel instrumentation. Three adult rhesus monkeys received microwire array implants, totaling 96-704 microwires per subject, in up to five cortical areas, sometimes bilaterally. Recordings 3-4 weeks after implantation yielded 421 single neurons with a mean peak-to-peak voltage of 115 +/- 3 microV and a signal-to-noise ratio of better than 5:1. As many as 247 cortical neurons were recorded in one session, and at least 58 neurons were isolated from one subject 18 months after implantation. This method should benefit neurophysiological investigation of learning, perception, and sensorimotor integration in primates and the development of neuroprosthetic devices.

Duke Scholars

Author Miguel Angelo L. Nicolelis Neurobiology

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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.1934665100

ISSN

0027-8424

Publication Date

September 16, 2003

Volume

100

Issue

Start / End Page

11041 / 11046

Location

United States

Related Subject Headings

Male
Macaca mulatta
Female
Electrodes
Cerebral Cortex
Animals
Action Potentials

Citation

APA

Chicago

ICMJE

MLA

NLM

Nicolelis, M. A. L., Dimitrov, D., Carmena, J. M., Crist, R., Lehew, G., Kralik, J. D., & Wise, S. P. (2003). Chronic, multisite, multielectrode recordings in macaque monkeys. Proc Natl Acad Sci U S A, 100(19), 11041–11046. https://doi.org/10.1073/pnas.1934665100

Nicolelis, Miguel A. L., Dragan Dimitrov, Jose M. Carmena, Roy Crist, Gary Lehew, Jerald D. Kralik, and Steven P. Wise. “Chronic, multisite, multielectrode recordings in macaque monkeys.” Proc Natl Acad Sci U S A 100, no. 19 (September 16, 2003): 11041–46. https://doi.org/10.1073/pnas.1934665100.

Nicolelis MAL, Dimitrov D, Carmena JM, Crist R, Lehew G, Kralik JD, et al. Chronic, multisite, multielectrode recordings in macaque monkeys. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11041–6.

Nicolelis, Miguel A. L., et al. “Chronic, multisite, multielectrode recordings in macaque monkeys.” Proc Natl Acad Sci U S A, vol. 100, no. 19, Sept. 2003, pp. 11041–46. Pubmed, doi:10.1073/pnas.1934665100.

Nicolelis MAL, Dimitrov D, Carmena JM, Crist R, Lehew G, Kralik JD, Wise SP. Chronic, multisite, multielectrode recordings in macaque monkeys. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11041–11046.

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.1934665100

ISSN

0027-8424

Publication Date

September 16, 2003

Volume

100

Issue

Start / End Page

11041 / 11046

Location

United States

Related Subject Headings

Male
Macaca mulatta
Female
Electrodes
Cerebral Cortex
Animals
Action Potentials