Whole genome genetic-typing in yeast using high-density oligonucleotide arrays.
Publication
, Journal Article
Winzeler, EA; Lee, B; McCusker, JH; Davis, RW
Published in: Parasitology
1999
Genome sequence information in combination with new technologies has allowed researchers to approach genetic problems in new ways. High-density oligonucleotide arrays were used to probe the genome content of the yeast Saccharomyces cerevisiae. We show that these arrays, containing oligonucleotides complementary to the sequenced strain of S. cerevisiae, can be used to identify open reading frames that are missing or present in higher or lower copy number in related isolates of S. cerevisiae. We apply this method to the characterization of the genome of a strain derived from a clinical isolate of S. cerevisiae. Our results show that the telomeres are the regions with the most variability between the two strains.
Duke Scholars
Published In
Parasitology
DOI
ISSN
0031-1820
Publication Date
1999
Volume
118 Suppl
Start / End Page
S73 / S80
Location
England
Related Subject Headings
- Saccharomyces cerevisiae
- Open Reading Frames
- Oligonucleotide Probes
- Oligonucleotide Array Sequence Analysis
- Mycology & Parasitology
- Genotype
- Genome, Fungal
- Genes, Fungal
- Gene Dosage
- Gene Deletion
Citation
APA
Chicago
ICMJE
MLA
NLM
Winzeler, E. A., Lee, B., McCusker, J. H., & Davis, R. W. (1999). Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology, 118 Suppl, S73–S80. https://doi.org/10.1017/s0031182099004047
Winzeler, E. A., B. Lee, J. H. McCusker, and R. W. Davis. “Whole genome genetic-typing in yeast using high-density oligonucleotide arrays.” Parasitology 118 Suppl (1999): S73–80. https://doi.org/10.1017/s0031182099004047.
Winzeler EA, Lee B, McCusker JH, Davis RW. Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology. 1999;118 Suppl:S73–80.
Winzeler, E. A., et al. “Whole genome genetic-typing in yeast using high-density oligonucleotide arrays.” Parasitology, vol. 118 Suppl, 1999, pp. S73–80. Pubmed, doi:10.1017/s0031182099004047.
Winzeler EA, Lee B, McCusker JH, Davis RW. Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology. 1999;118 Suppl:S73–S80.
Published In
Parasitology
DOI
ISSN
0031-1820
Publication Date
1999
Volume
118 Suppl
Start / End Page
S73 / S80
Location
England
Related Subject Headings
- Saccharomyces cerevisiae
- Open Reading Frames
- Oligonucleotide Probes
- Oligonucleotide Array Sequence Analysis
- Mycology & Parasitology
- Genotype
- Genome, Fungal
- Genes, Fungal
- Gene Dosage
- Gene Deletion